PMID- 22529850
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 3
DP  - 2012
TI  - Little evidence of systemic and adipose tissue inflammation in overweight 
      individuals(dagger).
PG  - 58
LID - 10.3389/fgene.2012.00058 [doi]
LID - 58
AB  - CONTEXT: The effect of weight loss by diet alone or diet in conjunction with 
      exercise on low-grade inflammation in non-obese (overweight) individuals is not 
      known. OBJECTIVE: Test the hypothesis that 24 weeks of moderate calorie 
      restriction (CR; 25%) by diet only or with aerobic exercise would reduce markers 
      of systemic inflammation and attenuate inflammation gene expression in 
      subcutaneous adipose tissue. DESIGN: Randomized controlled trial. SETTING: 
      Institutional Research Center. PARTICIPANTS: Thirty-five overweight (body mass 
      index: 27.8 +/- 0.7 kg/m(2)) but otherwise healthy participants (16M/19F) completed 
      the study. INTERVENTION: PARTICIPANTS were randomized to either CR (25% reduction 
      in energy intake, n = 12), caloric restriction + exercise (CR + EX: 12.5% 
      reduction in energy intake + 12.5% increase in exercise energy expenditure, n = 
      12), or control (healthy weight-maintenance diet, n = 11) for 6 months. MAIN 
      OUTCOME MEASURES: Fasting serum markers of inflammation [leptin, highly sensitive 
      C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor-alpha 
      (TNF-alpha), adiponectin] and inflammation-related genes [CD68, IL-6, TNF-alpha, 
      macrophage migration inhibitory factor (MIF), monocyte chemoattractant protein-1 
      (MCP-1), adiponectin, plasminogen activator inhibitor-1 (PAI-1)] in subcutaneous 
      adipose tissue. RESULTS: CR and CR + EX lost similar amounts of body weight (-10 
      +/- 1%), fat mass (-24 +/- 3%), visceral fat (-27 +/- 3%), and had increased insulin 
      sensitivity (CR: 40 +/- 20%, CR + EX: 66 +/- 22%). Leptin was significantly decreased 
      from baseline (p < 0.001) in both groups however TNF-alpha and IL-6 were not changed. 
      hsCRP was decreased in CR + EX. There was no change in the expression of genes 
      involved in macrophage infiltration (CD68, MIF MCP-1, PAI-1) or inflammation 
      (IL-6, TNF-alpha, adiponectin) in either CR or CR + EX. CONCLUSION: A 10% weight loss 
      with a 25% CR diet alone or with exercise did not impact markers of systemic 
      inflammation or the expression of inflammation-related adipose genes in 
      overweight individuals.
FAU - Tam, Charmaine S
AU  - Tam CS
AD  - Pennington Biomedical Research Center, Louisiana State University System, Baton 
      Rouge, LA, USA.
FAU - Covington, Jeffrey D
AU  - Covington JD
FAU - Ravussin, Eric
AU  - Ravussin E
FAU - Redman, Leanne M
AU  - Redman LM
CN  - Pennington CALERIE Team
LA  - eng
GR  - K99 HD060762/HD/NICHD NIH HHS/United States
GR  - P30 DK072476/DK/NIDDK NIH HHS/United States
GR  - R00 HD060762/HD/NICHD NIH HHS/United States
GR  - U01 AG020478/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20120419
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC3329711
OTO - NOTNLM
OT  - aging
OT  - caloric restriction
OT  - exercise
OT  - immune function
OT  - inflammation
OT  - subcutaneous fat
EDAT- 2012/04/25 06:00
MHDA- 2012/04/25 06:01
PMCR- 2012/04/19
CRDT- 2012/04/25 06:00
PHST- 2012/02/06 00:00 [received]
PHST- 2012/02/29 00:00 [accepted]
PHST- 2012/04/25 06:00 [entrez]
PHST- 2012/04/25 06:00 [pubmed]
PHST- 2012/04/25 06:01 [medline]
PHST- 2012/04/19 00:00 [pmc-release]
AID - 10.3389/fgene.2012.00058 [doi]
PST - epublish
SO  - Front Genet. 2012 Apr 19;3:58. doi: 10.3389/fgene.2012.00058. eCollection 2012.