PMID- 22530129
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-2662 (Electronic)
IS  - 2090-2654 (Print)
IS  - 2090-2654 (Linking)
VI  - 2012
DP  - 2012
TI  - Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?
PG  - 862169
LID - 10.1155/2012/862169 [doi]
LID - 862169
AB  - Recent advances in the field of neuromyelitis optica (NMO) research provided 
      convincing evidence that anti-AQP4 antibody (AQP4-Ab) not only serves as a highly 
      specific disease marker, but also plays an essential role in the pathogenesis of 
      the disease. Although it is now widely recognized that AQP4-Ab induces astrocytic 
      necrosis in a complement-dependent manner, additional triggers are also suspected 
      as a prerequisite for the development of the disease. Unraveling these unresolved 
      aspects of the disease will provide substantial insight into still controversial 
      issues in the pathogenesis of NMO.
FAU - Kinoshita, Makoto
AU  - Kinoshita M
AD  - Department of Neurology, Osaka University Graduate School of Medicine, D4, 2-2 
      Yamadaoka, Suita, Osaka 565-0871, Japan.
FAU - Nakatsuji, Yuji
AU  - Nakatsuji Y
LA  - eng
PT  - Journal Article
DEP - 20120312
PL  - Egypt
TA  - Mult Scler Int
JT  - Multiple sclerosis international
JID - 101566861
PMC - PMC3316941
EDAT- 2012/04/25 06:00
MHDA- 2012/04/25 06:01
PMCR- 2012/03/12
CRDT- 2012/04/25 06:00
PHST- 2011/10/27 00:00 [received]
PHST- 2011/12/28 00:00 [revised]
PHST- 2012/01/04 00:00 [accepted]
PHST- 2012/04/25 06:00 [entrez]
PHST- 2012/04/25 06:00 [pubmed]
PHST- 2012/04/25 06:01 [medline]
PHST- 2012/03/12 00:00 [pmc-release]
AID - 10.1155/2012/862169 [doi]
PST - ppublish
SO  - Mult Scler Int. 2012;2012:862169. doi: 10.1155/2012/862169. Epub 2012 Mar 12.