PMID- 22530602
OWN - NLM
STAT- MEDLINE
DCOM- 20121107
LR  - 20151119
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Linking)
VI  - 6
IP  - 6
DP  - 2012 Jun 26
TI  - Nanoparticle-assisted stimulated-emission-depletion nanoscopy.
PG  - 5291-6
LID - 10.1021/nn301082g [doi]
AB  - We show that metal nanoparticles can be used to improve the performance of 
      super-resolution fluorescence nanoscopes based on stimulated-emission-depletion 
      (STED). Compared with a standard STED nanoscope, we show theoretically a 
      resolution improvement by more than an order of magnitude, or equivalently, 
      depletion intensity reductions by more than 2 orders of magnitude and an even 
      stronger photostabilization. Our scheme may allow improvement of existing STED 
      nanoscopes and assist in the development of low-power, low-cost nanoscopes. This 
      has the potential to increase the availability of STED nanoscopes and lead to a 
      significant expansion of our understanding of biological and biochemical 
      phenomena occurring on the nanoscale.
FAU - Sivan, Yonatan
AU  - Sivan Y
AD  - The Blackett Laboratory, Department of Physics, Imperial College London, London 
      SW72AZ. ysivan@imperial.ac.uk
FAU - Sonnefraud, Yannick
AU  - Sonnefraud Y
FAU - Kena-Cohen, Stephane
AU  - Kena-Cohen S
FAU - Pendry, John B
AU  - Pendry JB
FAU - Maier, Stefan A
AU  - Maier SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120430
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - 0 (Contrast Media)
SB  - IM
MH  - Computer Simulation
MH  - Contrast Media
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Microscopy, Fluorescence/*methods
MH  - *Models, Theoretical
MH  - Molecular Imaging/*methods
MH  - Nanoparticles/*ultrastructure
MH  - Nanotechnology/*methods
EDAT- 2012/04/26 06:00
MHDA- 2012/11/08 06:00
CRDT- 2012/04/26 06:00
PHST- 2012/04/26 06:00 [entrez]
PHST- 2012/04/26 06:00 [pubmed]
PHST- 2012/11/08 06:00 [medline]
AID - 10.1021/nn301082g [doi]
PST - ppublish
SO  - ACS Nano. 2012 Jun 26;6(6):5291-6. doi: 10.1021/nn301082g. Epub 2012 Apr 30.