PMID- 22531464
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20201216
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 13
IP  - 11
DP  - 2012 Nov
TI  - Impact of gender differences on myocardial salvage and post-ischaemic left 
      ventricular remodelling after primary coronary angioplasty: new insights from 
      cardiovascular magnetic resonance.
PG  - 948-53
LID - 10.1093/ehjci/jes087 [doi]
AB  - AIMS: There is conflicting evidence on the impact of gender on reperfusion after 
      primary coronary angioplasty (PPCI), and on left ventricular (LV) remodelling 
      (LVR). In a cohort of patients with reperfused ST elevation myocardial infarction 
      (STEMI), gender-related differences on myocardial reperfusion, and sex-related 
      differences on LVR were assessed by using a comprehensive cardiac magnetic 
      resonance (CMR) approach. METHODS AND RESULTS: In four tertiary referral centres, 
      283 (238 males and 45 females) consecutive STEMI patients, treated with PPCI 
      within 12 h from symptoms onset underwent CMR 3 +/- 2 days after STEMI and at 
      4-month follow-up. By CMR, the area at risk, infarct size (IS), microvascular 
      obstruction (MVO), and myocardial salvage index (MSI) were assessed. Women were 
      older than men (P = 0.014), more hypertensive (P < 0.001) and more frequently 
      presented with pre-infarct angina (P = 0.018). An MSI extent was significantly 
      higher (P = 0.013), IS was significantly smaller at both time points (acute P < 
      0.001, follow-up P < 0.001), and the MVO extent was significantly smaller (P < 
      0.001) in women. At multivariate analysis, Killip class and female sex were 
      independently associated with a higher MSI (P = 0.02, P = 0.05, respectively). A 
      similar incidence of LVR in both sexes was observed at follow-up (P = 0.808). 
      CONCLUSIONS: The better reperfusion pattern observed in women by CMR in our 
      population of reperfused STEMI suggests sex-based differences exist. No gender 
      differences were observed with respect to incidence of LV remodelling at the 
      follow-up mainly occurring in the subset of patients with a larger IS.
FAU - Canali, Emanuele
AU  - Canali E
AD  - Department of Cardiology, Sapienza University of Rome, Viale del Policlinico 155, 
      00161 Roma, Italy.
FAU - Masci, Pier
AU  - Masci P
FAU - Bogaert, Jan
AU  - Bogaert J
FAU - Bucciarelli Ducci, Chiara
AU  - Bucciarelli Ducci C
FAU - Francone, Marco
AU  - Francone M
FAU - McAlindon, Elisa
AU  - McAlindon E
FAU - Carbone, Iacopo
AU  - Carbone I
FAU - Lombardi, Massimo
AU  - Lombardi M
FAU - Desmet, Walter
AU  - Desmet W
FAU - Janssens, Stefan
AU  - Janssens S
FAU - Agati, Luciano
AU  - Agati L
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20120424
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Age Factors
MH  - Aging
MH  - *Angioplasty, Balloon, Coronary
MH  - Female
MH  - Health Status Indicators
MH  - Heart Ventricles/*diagnostic imaging/pathology
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/drug therapy/*therapy
MH  - Myocardial Ischemia/diagnosis/*diagnostic imaging/pathology
MH  - Myocardial Reperfusion
MH  - Myocardium
MH  - Prospective Studies
MH  - Sex Factors
MH  - Statistics as Topic
MH  - Time Factors
MH  - Ultrasonography
MH  - *Ventricular Remodeling
EDAT- 2012/04/26 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/04/26 06:00
PHST- 2012/04/26 06:00 [entrez]
PHST- 2012/04/26 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - jes087 [pii]
AID - 10.1093/ehjci/jes087 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2012 Nov;13(11):948-53. doi: 
      10.1093/ehjci/jes087. Epub 2012 Apr 24.