PMID- 22531750
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20120508
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 517
IP  - 1
DP  - 2012 May 23
TI  - Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in 
      cancer-induced bone pain in rats.
PG  - 60-3
LID - 10.1016/j.neulet.2012.04.026 [doi]
AB  - In this study, we examined the involvement of chemokine monocyte chemoattractant 
      protein-1 (MCP-1) in the spinal cord of a rat model of cancer-induced bone pain 
      (CIBP). In this model, CIBP was established by an intramedullary injection of 
      Walker 256 cells into the tibia of rats. We observed a significant increase in 
      expression levels of MCP-1 and its receptor CCR2 in the spinal cord of CIBP rats. 
      Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing 
      antibody attenuated the mechanical allodynia established in CIBP rats. Likewise, 
      an intrathecal injection of exogenous recombinant MCP-1 induced a striking 
      mechanical allodynia in naive rats. These results suggest that increases in 
      spinal MCP-1 and CCR2 expression are involved in the development of mechanical 
      allodynia associated with bone cancer rats.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Hu, Ji-Hua
AU  - Hu JH
AD  - Department of Anesthesiology, The First Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu 215006, China.
FAU - Zheng, Xiao-Yan
AU  - Zheng XY
FAU - Yang, Jian-Ping
AU  - Yang JP
FAU - Wang, Li-Na
AU  - Wang LN
FAU - Ji, Fu-Hai
AU  - Ji FH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120415
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Animals
MH  - Bone Neoplasms/*metabolism/secondary
MH  - Chemokine CCL2/genetics/*metabolism/pharmacology
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Hyperalgesia/complications/therapy
MH  - Injections, Spinal
MH  - Pain/etiology/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, CCR2/metabolism
MH  - Spinal Cord/metabolism
EDAT- 2012/04/26 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/04/26 06:00
PHST- 2012/02/12 00:00 [received]
PHST- 2012/04/06 00:00 [revised]
PHST- 2012/04/08 00:00 [accepted]
PHST- 2012/04/26 06:00 [entrez]
PHST- 2012/04/26 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - S0304-3940(12)00546-0 [pii]
AID - 10.1016/j.neulet.2012.04.026 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 May 23;517(1):60-3. doi: 10.1016/j.neulet.2012.04.026. Epub 
      2012 Apr 15.