PMID- 22531936
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 39
IP  - 8
DP  - 2012 Aug
TI  - Effects of retrograde gene transfer of brain-derived neurotrophic factor in the 
      rostral spinal cord of a compression model in rat.
PG  - 8045-51
LID - 10.1007/s11033-012-1651-7 [doi]
AB  - Recovery after spinal cord injury (SCI) is rare in humans and experimental 
      animals. Following SCI in adults, changes in gene expression and the regulation 
      of these genes are associated with the pathological development of the injury. 
      High levels of brain-derived neurotrophic factor (BDNF) in the injury area during 
      the post-injury period contribute to enhanced neuroprotection and axonal 
      regeneration. Intervention at the level of gene regulation has the potential to 
      promote SCI repair. In this study, the injection of adenovirus-mediated BDNF in 
      the lesion area (rostral spinal cord) up-regulated the expression of BDNF in the 
      injury zone of a compression model in rat, thereby protecting neurons and 
      enhancing behavioral function.
FAU - Zhao, Tengfei
AU  - Zhao T
AD  - The Second Affiliated Hospital (Binjiang Branch), Hangzhou Binjiang Hospital, 
      Zhejiang University School of Medicine, Hangzhou 310000, China.
FAU - Li, Yan
AU  - Li Y
FAU - Dai, Xuesong
AU  - Dai X
FAU - Wang, Junbo
AU  - Wang J
FAU - Qi, Yiying
AU  - Qi Y
FAU - Wang, Jianwei
AU  - Wang J
FAU - Xu, Kan
AU  - Xu K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120425
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adenoviridae/genetics
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - *Gene Transfer Techniques
MH  - Genes, Reporter
MH  - Genetic Vectors/administration & dosage
MH  - Motor Activity/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Compression/*genetics/*metabolism
EDAT- 2012/04/26 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/04/26 06:00
PHST- 2011/08/11 00:00 [received]
PHST- 2012/04/16 00:00 [accepted]
PHST- 2012/04/26 06:00 [entrez]
PHST- 2012/04/26 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1007/s11033-012-1651-7 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2012 Aug;39(8):8045-51. doi: 10.1007/s11033-012-1651-7. Epub 2012 
      Apr 25.