PMID- 22532637
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20191210
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 71
IP  - 7
DP  - 2012 Jul
TI  - Serum IL-6 and IL-21 are associated with markers of B cell activation and 
      structural progression in early rheumatoid arthritis: results from the ESPOIR 
      cohort.
PG  - 1243-8
LID - 10.1136/annrheumdis-2011-200975 [doi]
AB  - OBJECTIVE: To identify a specific pattern of serum cytokines that correlates with 
      the diagnosis, activity and severity of rheumatoid arthritis (RA) in patients 
      with early RA as well as with the level of serum markers of B cell activation. 
      METHODS: Serum interleukin (IL)-1beta, IL-1 receptor antagonist (IL1-Ra), IL-2, 
      IL-4, IL-6, IL-10, IL-17, IL-21, monocyte chemotactic protein 1 (MCP-1), tumour 
      necrosis factor alpha and interferon gamma levels were measured in the (ESPOIR) Etude et 
      Suivi des POlyarthrites Indifferenciees Recentes early arthritis cohort, which 
      included patients with at least two swollen joints for >6 weeks and <6 months, 
      and no previous corticosteroids or disease-modifying antirheumatic drugs. Serum 
      cytokine levels were compared between patients who met the 1987 American College 
      of Rheumatology criteria for RA (n=578) or had undifferentiated arthritis (UA, 
      n=132) at the 1-year follow-up visit. RESULTS: Serum IL-6 and IL-21 were the only 
      cytokines that discriminated RA from UA on univariate analysis. IL-6 level was 
      associated with RA, whereas erythrocyte sedimentation rate and C-reactive protein 
      were not. Higher proportions of rheumatoid factor and anticyclic citrullinated 
      protein (CCP) positivity, levels of markers of B cell activation, and a higher 
      frequency of rapid radiographic progression were observed in patients with RA 
      with detectable IL-6 or IL-21. Multivariate analysis associated IL-6 and anti-CCP 
      levels with radiographic erosions at enrolment with 1-year radiographic 
      progression. CONCLUSION: Serum IL-6 concentration is greater in RA than in UA. 
      Increase in serum IL-6 and IL-21 levels is associated with markers of B cell 
      activation, and IL-6 is associated with radiographic progression in patients with 
      RA.
FAU - Gottenberg, Jacques-Eric
AU  - Gottenberg JE
AD  - Department of Rheumatology, EA 4438, Strasbourg University Hospital, Hopital 
      Hautepierre, 1 Avenue Moliere, 67000 Strasbourg, France. 
      jacques-eric.gottenberg@chru-strasbourg.fr
FAU - Dayer, Jean-Michel
AU  - Dayer JM
FAU - Lukas, Cedric
AU  - Lukas C
FAU - Ducot, Beatrice
AU  - Ducot B
FAU - Chiocchia, Gilles
AU  - Chiocchia G
FAU - Cantagrel, Alain
AU  - Cantagrel A
FAU - Saraux, Alain
AU  - Saraux A
FAU - Roux-Lombard, Pascale
AU  - Roux-Lombard P
FAU - Mariette, Xavier
AU  - Mariette X
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120424
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukins)
RN  - MKM3CA6LT1 (interleukin-21)
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/blood/*diagnosis/immunology
MH  - B-Lymphocytes/*immunology/metabolism/pathology
MH  - Biomarkers/blood
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Hyperalgesia/pathology/physiopathology
MH  - Interleukin-6/*blood
MH  - Interleukins/*blood
MH  - Joints/pathology/physiopathology
MH  - *Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Prospective Studies
EDAT- 2012/04/26 06:00
MHDA- 2012/08/22 06:00
CRDT- 2012/04/26 06:00
PHST- 2012/04/26 06:00 [entrez]
PHST- 2012/04/26 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - annrheumdis-2011-200975 [pii]
AID - 10.1136/annrheumdis-2011-200975 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2012 Jul;71(7):1243-8. doi: 10.1136/annrheumdis-2011-200975. Epub 
      2012 Apr 24.