PMID- 22533437
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20161125
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 15
IP  - 2
DP  - 2012 Apr
TI  - Plasmonic photothermic and stem cell therapy of atherosclerotic plaque as a novel 
      nanotool for angioplasty and artery remodeling.
PG  - 222-30
LID - 10.1089/rej.2011.1305 [doi]
AB  - BACKGROUND: Some modern angioplasty techniques drastically affect the geometry of 
      the plaque and the lumen, but have some inherent clinical and technical 
      limitations. METHODS: A total of 101 Yucatan miniature swine were allocated to 
      the three following groups (34 pigs into 60/15- to 70/40-nm silica-gold 
      nanoparticles (NPs), 34 swine into ferromagnetic group with iron-bearing NPs and 
      delivery in hand of magnetic fields, and 33 in a sirolimus stenting control). 
      Animals in the nanogroup were subdivided further into four subsets according to 
      the delivery approach: (1) Intracoronary infused circulating stem progenitor 
      cells (SPCs), including SP(+) (side population) cells, (2) intracoronary infused, 
      ultrasound-mediated, albumin-coated, gas-filled microbubbles, (3) CD73(+)105(+) 
      SPCs in the composition of a bioengineered on-artery patch (cardiac surgery), (4) 
      CD73(+)CD105(+) SPCs engrafted by manual subadventitial injection (cardiac 
      surgery). NPs were detonated with a microwatt near-infrared (NIR) laser (821 nm, 
      35-44 W/cm(2) for 7 min of exposure). RESULTS: Changes of the total atheroma 
      volume (TAV; mm(3)) immediately after the laser irradiation at month 6 in the 
      nanoshell, ferromagnetic, and control groups were -7.54%/-22.92%, -9.7%/-16.84%, 
      and -10.5%/-7.06% (p<0.01), respectively, and in the subsets reached 
      -2.79%/-21.92%, -6.26%/-15.24%, -4.6%/-31.21%, -16.5%/-23.3% (p<0.05), 
      respectively. Some cases of atherothrombosis and distal embolism (23.5%) were 
      documented only in the microbubbles subset. The impact of the therapy on the 
      nonorganic part of the plaque-antiinflammative and antiapoptotic effects, signs 
      of neovascularization, and restoration of artery function-were predominant in the 
      observed subsets with SPCs (p<0.01). CONCLUSION: Nanoburning, especially in 
      combination with stem cell technologies, is a very challenging technique for 
      altering advanced plaque and holds the promise of revolutionizing 
      state-of-the-art interventional cardiology, assuring destruction of plaque and 
      functional restoration of the vessel wall. It could potentially become the 
      current mechanical and pharmacological treatment.
FAU - Kharlamov, Alexander N
AU  - Kharlamov AN
AD  - Department of Science, Ural Institute of Cardiology, Yekaterinburg, Russia. 
      drskharlamov@gmail.com
FAU - Gabinsky, Jan L
AU  - Gabinsky JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (Albumins)
RN  - 7440-57-5 (Gold)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Albumins/chemistry
MH  - Angioplasty/*methods
MH  - Animals
MH  - Cell- and Tissue-Based Therapy/*methods
MH  - Coronary Vessels/*diagnostic imaging/pathology
MH  - Gold/chemistry
MH  - Magnetic Fields
MH  - Metal Nanoparticles/chemistry
MH  - Plaque, Atherosclerotic/*therapy
MH  - Silicon Dioxide/chemistry
MH  - Sirolimus/pharmacology
MH  - Stem Cells/*cytology
MH  - Swine
MH  - Swine, Miniature
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ultrasonography, Interventional
EDAT- 2012/04/27 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/04/27 06:00
PHST- 2012/04/27 06:00 [entrez]
PHST- 2012/04/27 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - 10.1089/rej.2011.1305 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2012 Apr;15(2):222-30. doi: 10.1089/rej.2011.1305.