PMID- 22534049
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20211021
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 5
DP  - 2012 Apr 25
TI  - Intra coronary freshly isolated bone marrow cells transplantation improve cardiac 
      function in patients with ischemic heart disease.
PG  - 195
LID - 10.1186/1756-0500-5-195 [doi]
AB  - BACKGROUND: Autologous bone marrow cell transplantation (BMCs-Tx) is a promising 
      novel option for treatment of cardiovascular disease. In this study we analyzed 
      whether intracoronary autologous freshly isolated BMCs-Tx have beneficial effects 
      on cardiac function in patients with ischemic heart disease (IHD). RESULTS: In 
      this prospective nonrandomized study we treated 12 patients with IHD by freshly 
      isolated BMCs-Tx by use of point of care system and compared them with a 
      representative 12 control group without cell therapy. Global ejection fraction 
      (EF) and infarct size area were determined by left ventriculography.Intracoronary 
      transplantation of autologous freshly isolated BMCs led to a significant 
      reduction of infarct size (p < 0.001) and an increase of global EF (p = 0.003) as 
      well as infarct wall movement velocity (p < 0.001) after 6 months follow-up 
      compared to control group. In control group there were no significant differences 
      of global EF, infarct size and infarct wall movement velocity between baseline 
      and 6 months after coronary angiography. Furthermore, we found significant 
      decrease in New York Heart Association (NYHA) as well as significant decrease of 
      B-type natriuretic peptide (BNP) level 6 months after intracoronary cell therapy 
      (p < 0.001), whereas there were no significant differences in control group 
      6 months after coronary angiography. CONCLUSIONS: These results demonstrate that 
      intracoronary transplantation of autologous freshly isolated BMCs by use of point 
      of care system is safe and may lead to improvement of cardiac function in 
      patients with IHD. REGISTRATION NUMBER: ISRCTN54510226.
FAU - Bozdag-Turan, Ilkay
AU  - Bozdag-Turan I
AD  - Department of Internal Medicine, Division of Cardiology, Rostock-University, 
      Ernst Hydemann Str 6, Rostock 18055, Germany.
FAU - Turan, R Goekmen
AU  - Turan RG
FAU - Ludovicy, Sophie
AU  - Ludovicy S
FAU - Akin, Ibrahim
AU  - Akin I
FAU - Kische, Stephan
AU  - Kische S
FAU - Schneider, Henrik
AU  - Schneider H
FAU - Rehders, Tim C
AU  - Rehders TC
FAU - Turan, C Hakan
AU  - Turan CH
FAU - Arsoy, Nicole S
AU  - Arsoy NS
FAU - Hermann, Tina
AU  - Hermann T
FAU - Paranskaya, Liliya
AU  - Paranskaya L
FAU - Ortak, Jasmin
AU  - Ortak J
FAU - Kohlschein, Peter
AU  - Kohlschein P
FAU - Bastian, Manuela
AU  - Bastian M
FAU - Sahin, Kurtulus
AU  - Sahin K
FAU - Nienaber, Christoph A
AU  - Nienaber CA
FAU - Ince, Hueseyin
AU  - Ince H
LA  - eng
SI  - ISRCTN/ISRCTN54510226
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120425
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - *Bone Marrow Transplantation
MH  - *Cell Separation/methods
MH  - Coronary Angiography
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Myocardial Infarction/blood/diagnostic imaging/pathology/physiopathology/*surgery
MH  - Myocardial Ischemia/blood/diagnostic imaging/pathology/physiopathology/*surgery
MH  - Myocardium/pathology
MH  - Natriuretic Peptide, Brain/blood
MH  - Point-of-Care Systems
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Stroke Volume
MH  - Time Factors
MH  - Transplantation, Autologous
MH  - Treatment Outcome
MH  - *Ventricular Function, Left
PMC - PMC3436745
EDAT- 2012/04/27 06:00
MHDA- 2013/02/01 06:00
PMCR- 2012/04/25
CRDT- 2012/04/27 06:00
PHST- 2011/11/08 00:00 [received]
PHST- 2012/04/05 00:00 [accepted]
PHST- 2012/04/27 06:00 [entrez]
PHST- 2012/04/27 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
PHST- 2012/04/25 00:00 [pmc-release]
AID - 1756-0500-5-195 [pii]
AID - 10.1186/1756-0500-5-195 [doi]
PST - epublish
SO  - BMC Res Notes. 2012 Apr 25;5:195. doi: 10.1186/1756-0500-5-195.