PMID- 22534108
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20220409
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 154
IP  - 1
DP  - 2012 Jul
TI  - Photoreceptor damage and foveal sensitivity in surgically closed macular holes: 
      an adaptive optics scanning laser ophthalmoscopy study.
PG  - 174-186.e2
LID - 10.1016/j.ajo.2012.01.031 [doi]
AB  - PURPOSE: To assess photoreceptor structure using adaptive optics scanning laser 
      ophthalmoscopy (AO SLO) and spectral-domain optical coherence tomography (SD OCT) 
      and to evaluate the relationship between structural abnormalities and foveal 
      sensitivity in eyes with surgically closed macular hole (MH). DESIGN: 
      Prospective, interventional case series. METHODS: Twenty-one eyes of 19 patients 
      with idiopathic MH underwent a full ophthalmologic examination, including SD OCT 
      at baseline. Imaging with SD OCT, an original prototype AO SLO system, and 
      microperimetry were performed at 6 months after surgery. RESULTS: All patients 
      underwent anatomically successful MH closure. On AO SLO, dark areas (0.004 to 
      0.754 mm(2)) were seen in all eyes after MH repair. Lower cone density correlated 
      with poorer postoperative visual acuity and lower mean foveal sensitivity (both P 
      < .001). Larger dark areas on AO SLO correlated with poorer postoperative visual 
      acuity (P = .003) and lower mean foveal sensitivity (P = .006). Cone density was 
      significantly lower and dark areas were significantly larger in eyes that had 
      defects of the outer segments in the fluid cuff before surgery (P = .018 and P = 
      .001, respectively) and moderately reflective foveal lesions after surgery (P < 
      .001 and P < .001, respectively). Larger dark areas correlated with longer 
      symptom duration before surgery (P < .001). CONCLUSIONS: Structural damage to the 
      photoreceptor layer correlated with greater decreases in visual function in eyes 
      with surgically closed MH. AO SLO imaging is a useful and quantitative tool for 
      detecting photoreceptor abnormalities and their association with visual acuity 
      and retinal sensitivity in eyes with closed MH.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Ooto, Sotaro
AU  - Ooto S
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan. ohoto@kuhp.kyoto-u.ac.jp
FAU - Hangai, Masanori
AU  - Hangai M
FAU - Takayama, Kohei
AU  - Takayama K
FAU - Ueda-Arakawa, Naoko
AU  - Ueda-Arakawa N
FAU - Hanebuchi, Masaaki
AU  - Hanebuchi M
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120424
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Basement Membrane/surgery
MH  - Endotamponade
MH  - Female
MH  - Fovea Centralis/*physiology
MH  - Humans
MH  - Lasers
MH  - Male
MH  - Middle Aged
MH  - *Ophthalmoscopy
MH  - Photoreceptor Cells, Vertebrate/*pathology
MH  - Prone Position
MH  - Prospective Studies
MH  - Retinal Perforations/physiopathology/*surgery
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/*physiology
MH  - Visual Field Tests
MH  - Vitrectomy
EDAT- 2012/04/27 06:00
MHDA- 2012/08/30 06:00
CRDT- 2012/04/27 06:00
PHST- 2011/11/09 00:00 [received]
PHST- 2012/01/31 00:00 [revised]
PHST- 2012/01/31 00:00 [accepted]
PHST- 2012/04/27 06:00 [entrez]
PHST- 2012/04/27 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - S0002-9394(12)00082-7 [pii]
AID - 10.1016/j.ajo.2012.01.031 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2012 Jul;154(1):174-186.e2. doi: 10.1016/j.ajo.2012.01.031. Epub 
      2012 Apr 24.