PMID- 22534136
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20220310
IS  - 1873-4022 (Electronic)
IS  - 1873-4022 (Linking)
VI  - 37
IP  - 4
DP  - 2012 Winter
TI  - Implant breast reconstruction followed by radiotherapy: can helical tomotherapy 
      become a standard irradiation treatment?
PG  - 425-31
LID - S0958-3947(12)00064-7 [pii]
LID - 10.1016/j.meddos.2012.03.006 [doi]
AB  - To evaluate the benefits and limitations of helical tomotherapy (HT) for 
      loco-regional irradiation of patients after a mastectomy and immediate 
      implant-based reconstruction. Ten breast cancer patients with retropectoral 
      implants were randomly selected for this comparative study. Planning target 
      volumes (PTVs) 1 (the volume between the skin and the implant, plus margin) and 2 
      (supraclavicular, infraclavicular, and internal mammary nodes, plus margin) were 
      50 Gy in 25 fractions using a standard technique and HT. The extracted dosimetric 
      data were compared using a 2-tailed Wilcoxon matched-pair signed-rank test. Doses 
      for PTV1 and PTV2 were significantly higher with HT (V95 of 98.91 and 97.91%, 
      respectively) compared with the standard technique (77.46 and 72.91%, 
      respectively). Similarly, the indexes of homogeneity were significantly greater 
      with HT (p = 0.002). HT reduced ipsilateral lung volume that received >/=20 Gy 
      (16.7 vs. 35%), and bilateral lungs (p = 0.01) and neighboring organs received 
      doses that remained well below tolerance levels. The heart volume, which received 
      25 Gy, was negligible with both techniques. HT can achieve full target coverage 
      while decreasing high doses to the heart and ipsilateral lung. However, the low 
      doses to normal tissue volumes need to be reduced in future studies.
CI  - Copyright (c) 2012 American Association of Medical Dosimetrists. Published by 
      Elsevier Inc. All rights reserved.
FAU - Massabeau, Carole
AU  - Massabeau C
AD  - Department of Radiation Oncology, Institut Curie, Paris, France. 
      cmassabeau@hotmail.com
FAU - Fournier-Bidoz, Nathalie
AU  - Fournier-Bidoz N
FAU - Wakil, Georges
AU  - Wakil G
FAU - Castro Pena, Pablo
AU  - Castro Pena P
FAU - Viard, Romain
AU  - Viard R
FAU - Zefkili, Sofia
AU  - Zefkili S
FAU - Reyal, Fabien
AU  - Reyal F
FAU - Campana, Francois
AU  - Campana F
FAU - Fourquet, Alain
AU  - Fourquet A
FAU - Kirova, Youlia M
AU  - Kirova YM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120424
PL  - United States
TA  - Med Dosim
JT  - Medical dosimetry : official journal of the American Association of Medical 
      Dosimetrists
JID - 8908862
SB  - IM
MH  - *Breast Implants
MH  - Breast Neoplasms/*therapy
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Mammaplasty/*instrumentation/methods
MH  - Radiometry/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Adjuvant/methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Treatment Outcome
EDAT- 2012/04/27 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/04/27 06:00
PHST- 2011/11/11 00:00 [received]
PHST- 2012/02/24 00:00 [revised]
PHST- 2012/03/15 00:00 [accepted]
PHST- 2012/04/27 06:00 [entrez]
PHST- 2012/04/27 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - S0958-3947(12)00064-7 [pii]
AID - 10.1016/j.meddos.2012.03.006 [doi]
PST - ppublish
SO  - Med Dosim. 2012 Winter;37(4):425-31. doi: 10.1016/j.meddos.2012.03.006. Epub 2012 
      Apr 24.