PMID- 22536232
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Print)
IS  - 1687-8337 (Linking)
VI  - 2012
DP  - 2012
TI  - Hyperandrogenism Does Not Influence Metabolic Parameters in Adolescent Girls with 
      PCOS.
PG  - 434830
LID - 10.1155/2012/434830 [doi]
LID - 434830
AB  - Background. Underlying insulin resistance and/or obesity has clearly been 
      implicated in the development of metabolic syndrome in adolescents and young 
      adults with polycystic ovarian syndrome (PCOS). It is not clear however what role 
      hyperandrogenism has on the development of metabolic syndrome or its role on 
      those metabolic parameters associated with metabolic syndrome. Methods. We 
      studied 107 adolescent girls; 54 had PCOS according to NIH criteria. Data was 
      obtained for systolic and diastolic blood pressure (SBP and DBP), body mass index 
      (BMI), total testosterone (T), luteinizing hormone (LH), follicle-stimulating 
      hormone (FSH), prolactin, fasting lipid profile, and glucose. The PCOS group was 
      divided initially into subgroups according to BMI (kg/m(2)), then based on T 
      (ng/dL) levels as follows: High Testosterone PCOS (HT), Intermediate Testosterone 
      PCOS (IT), Obese and Normal Testosterone (ONT), and lean and normal T (Control, 
      C). t-test analysis was performed in between all the groups. Results. There was 
      no statistical difference between HT and IT, HT and ONT, or IT and ONT in SBP, 
      DBP, fasting blood glucose, lipid panel, LH, FSH, and prolactin levels. The 
      control group had lower SBP and BMI comparing with ONT, IT, and HT groups. There 
      were no statistical differences found in DBP, fasting blood glucose, lipid panel, 
      LH, FSH, or Prolactin. Conclusion. Metabolic profile in adolescent girls with 
      PCOS is not affected by either the presence of hyperandrogenism or the degree of 
      hyperandrogenism.
FAU - Forrester-Dumont, Kim
AU  - Forrester-Dumont K
AD  - Division of Adolescent Medicine, The Children's Hospital at SUNY Downstate, 
      Brooklyn, NY, USA.
FAU - Galescu, Ovidiu
AU  - Galescu O
FAU - Kolesnikov, Andrey
AU  - Kolesnikov A
FAU - Raissouni, Nouhad
AU  - Raissouni N
FAU - Bhangoo, Amrit
AU  - Bhangoo A
FAU - Ten, Svetlana
AU  - Ten S
FAU - Suss, Amy
AU  - Suss A
LA  - eng
PT  - Journal Article
DEP - 20120327
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC3320022
EDAT- 2012/04/27 06:00
MHDA- 2012/04/27 06:01
PMCR- 2012/03/27
CRDT- 2012/04/27 06:00
PHST- 2011/11/20 00:00 [received]
PHST- 2012/01/22 00:00 [revised]
PHST- 2012/01/23 00:00 [accepted]
PHST- 2012/04/27 06:00 [entrez]
PHST- 2012/04/27 06:00 [pubmed]
PHST- 2012/04/27 06:01 [medline]
PHST- 2012/03/27 00:00 [pmc-release]
AID - 10.1155/2012/434830 [doi]
PST - ppublish
SO  - Int J Endocrinol. 2012;2012:434830. doi: 10.1155/2012/434830. Epub 2012 Mar 27.