PMID- 22541401
OWN - NLM
STAT- MEDLINE
DCOM- 20120627
LR  - 20120430
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 108
IP  - 5
DP  - 2012 May
TI  - Respiratory syncytial virus infection increases regulated on activation normal T 
      cell expressed and secreted and monocyte chemotactic protein 1 levels in serum of 
      patients with asthma and in human monocyte cultures.
PG  - 316-20
LID - 10.1016/j.anai.2012.03.006 [doi]
AB  - BACKGROUND: Respiratory syncytial virus (RSV) infection is associated to episodic 
      exacerbations of asthma involving alveolar macrophages and chemokine production. 
      OBJECTIVE: The aim of this study was to determine the circulating levels of 
      monocyte chemotactic protein 1 (MCP-1), regulated on activation normal T cell 
      expressed and secreted (RANTES), and substance P (SP) in patients with and 
      without asthma with acute respiratory RSV infection and the chemokine profile in 
      RSV- infected monocyte cultures from normal individuals and individuals with 
      asthma. METHODS: In this regard, 31 adult patients with acute respiratory 
      infection (15 patients with asthma) were studied. MCP-1, RANTES and SP were 
      measured in serum and in supernatants from monocyte cultures by enzyme-linked 
      immunosorbent assay (ELISA). RESULTS: Increased levels of MCP-1 and RANTES were 
      observed in serum from patients with asthma related to RSV infection. 
      RSV-infected monocyte cultures from healthy individuals showed increased content 
      of those chemokines, and monocyte cultures from patients with asthma showed 
      increased expression of MCP-1. CONCLUSION: These data show that RSV infection 
      induces increased circulating level of chemokines in patients with asthma, and 
      this finding could be mediated in part by the interaction virus-monocyte.
CI  - Copyright (c) 2012 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Gotera, Jenifer
AU  - Gotera J
AD  - Instituto de Investigaciones Clinicas Dr. Americo Negrette, Facultad de Medicina, 
      Universidad del Zulia, Maracaibo, Venezuela.
FAU - Giuffrida, Maria
AU  - Giuffrida M
FAU - Mavarez, Alibeth
AU  - Mavarez A
FAU - Pons, Hector
AU  - Pons H
FAU - Bermudez, John
AU  - Bermudez J
FAU - Maldonado, Mery
AU  - Maldonado M
FAU - Espina, Luz Marina
AU  - Espina LM
FAU - Mosquera, Jesus
AU  - Mosquera J
FAU - Valero, Nereida
AU  - Valero N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asthma/*immunology/metabolism/physiopathology
MH  - Cells, Cultured
MH  - Chemokine CCL2/*blood
MH  - Chemokine CCL5/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - Respiratory Syncytial Virus Infections/*immunology/metabolism/virology
MH  - Respiratory Syncytial Virus, Human/*immunology
MH  - Substance P/blood
MH  - T-Lymphocytes/*immunology
MH  - Up-Regulation
EDAT- 2012/05/01 06:00
MHDA- 2012/06/28 06:00
CRDT- 2012/05/01 06:00
PHST- 2011/12/08 00:00 [received]
PHST- 2012/02/28 00:00 [revised]
PHST- 2012/03/05 00:00 [accepted]
PHST- 2012/05/01 06:00 [entrez]
PHST- 2012/05/01 06:00 [pubmed]
PHST- 2012/06/28 06:00 [medline]
AID - S1081-1206(12)00181-0 [pii]
AID - 10.1016/j.anai.2012.03.006 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2012 May;108(5):316-20. doi: 
      10.1016/j.anai.2012.03.006.