PMID- 22541561
OWN - NLM
STAT- MEDLINE
DCOM- 20120625
LR  - 20221207
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Print)
IS  - 0002-9297 (Linking)
VI  - 90
IP  - 5
DP  - 2012 May 4
TI  - A genome-wide association study reveals that variants within the HLA region are 
      associated with risk for nonobstructive azoospermia.
PG  - 900-6
LID - 10.1016/j.ajhg.2012.04.001 [doi]
AB  - A genome-wide association study of Han Chinese subjects was conducted to identify 
      genetic susceptibility loci for nonobstructive azoospermia (NOA). In the 
      discovery stage, 802 azoospermia cases and 1,863 controls were screened for 
      genetic variants in the genome. Promising SNPs were subsequently confirmed in two 
      independent sets of subjects: 818 azoospermia cases and 1,755 controls from 
      northern China, and 606 azoospermia cases and 958 controls from central and 
      southern China. We detected variants at human leukocyte antigen (HLA) regions 
      that were independently associated with NOA (HLA-DRA, rs3129878, p(combine) = 
      3.70 x 10(-16), odds ratio [OR] = 1.37; C6orf10 and BTNL2, rs498422, p(combine) = 
      2.43 x 10(-12), OR = 1.42). These findings provide additional insight into the 
      pathogenesis of NOA.
CI  - Copyright (c) 2012 The American Society of Human Genetics. Published by Elsevier 
      Inc. All rights reserved.
FAU - Zhao, Han
AU  - Zhao H
AD  - Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong 
      University, 324 Jingwu Road, Jinan, Shandong, China.
FAU - Xu, Jianfeng
AU  - Xu J
FAU - Zhang, Haobo
AU  - Zhang H
FAU - Sun, Jielin
AU  - Sun J
FAU - Sun, Yingpu
AU  - Sun Y
FAU - Wang, Zhong
AU  - Wang Z
FAU - Liu, Jiayin
AU  - Liu J
FAU - Ding, Qiang
AU  - Ding Q
FAU - Lu, Shaoming
AU  - Lu S
FAU - Shi, Rong
AU  - Shi R
FAU - You, Li
AU  - You L
FAU - Qin, Yingying
AU  - Qin Y
FAU - Zhao, Xiaoming
AU  - Zhao X
FAU - Lin, Xiaoling
AU  - Lin X
FAU - Li, Xiao
AU  - Li X
FAU - Feng, Junjie
AU  - Feng J
FAU - Wang, Li
AU  - Wang L
FAU - Trent, Jeffrey M
AU  - Trent JM
FAU - Xu, Chengyan
AU  - Xu C
FAU - Gao, Ying
AU  - Gao Y
FAU - Zhang, Bo
AU  - Zhang B
FAU - Gao, Xuan
AU  - Gao X
FAU - Hu, Jingmei
AU  - Hu J
FAU - Chen, Hong
AU  - Chen H
FAU - Li, Guangyu
AU  - Li G
FAU - Zhao, Junzhao
AU  - Zhao J
FAU - Zou, Shuhua
AU  - Zou S
FAU - Jiang, Hong
AU  - Jiang H
FAU - Hao, Cuifang
AU  - Hao C
FAU - Zhao, Yueran
AU  - Zhao Y
FAU - Ma, Jinglong
AU  - Ma J
FAU - Zheng, S Lilly
AU  - Zheng SL
FAU - Chen, Zi-Jiang
AU  - Chen ZJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120426
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Azoospermia/*epidemiology/*genetics
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Genetic Loci
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study/*methods
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
PMC - PMC3376492
EDAT- 2012/05/01 06:00
MHDA- 2012/06/26 06:00
PMCR- 2012/11/04
CRDT- 2012/05/01 06:00
PHST- 2011/09/17 00:00 [received]
PHST- 2012/03/07 00:00 [revised]
PHST- 2012/04/02 00:00 [accepted]
PHST- 2012/05/01 06:00 [entrez]
PHST- 2012/05/01 06:00 [pubmed]
PHST- 2012/06/26 06:00 [medline]
PHST- 2012/11/04 00:00 [pmc-release]
AID - S0002-9297(12)00201-7 [pii]
AID - AJHG1131 [pii]
AID - 10.1016/j.ajhg.2012.04.001 [doi]
PST - ppublish
SO  - Am J Hum Genet. 2012 May 4;90(5):900-6. doi: 10.1016/j.ajhg.2012.04.001. Epub 
      2012 Apr 26.