PMID- 22542551
OWN - NLM
STAT- MEDLINE
DCOM- 20121017
LR  - 20120611
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 216
DP  - 2012 Aug 2
TI  - Association of brain-derived neurotrophic factor and tyrosine kinase B receptor 
      in pregnancy.
PG  - 31-7
LID - 10.1016/j.neuroscience.2012.04.016 [doi]
AB  - Abnormal brain development in a compromised prenatal and/or early postnatal 
      environment is thought to be a risk factor for several neurobehavioural 
      disorders. However, the mechanisms underlying these are not well understood. We 
      have earlier reported reduced placental docosahexaenoic acid (DHA) levels in 
      preterm deliveries. We have hypothesized that increased oxidative stress and 
      reduced DHA levels may lead to changes in the circulating levels of maternal and 
      cord brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B 
      (TrkB) levels. A total number of 96 women delivering preterm and 95 women 
      delivering at term were recruited. Plasma BDNF levels were measured in both 
      mother and cord blood plasma using the BDNF Immuno Assay kit. Placental TrkB 
      levels were analysed using sandwich enzyme-linked immunosorbent assay (ELISA). 
      Maternal plasma BDNF levels and placental TrkB levels were higher (p<0.05) while 
      cord plasma BDNF levels were lower (p<0.01) in women delivering preterm as 
      compared to term. There was a negative association between levels of placental 
      TrkB and DHA (p=0.034). A negative association between maternal plasma BDNF 
      levels and placental weight (p=0.001) was observed while a positive association 
      was seen between cord plasma BDNF levels and gestation (p=0.025). The reduction 
      in cord BDNF levels may have implications for altered neurodevelopment in 
      childhood and later life. Studies need to be undertaken to follow up children 
      born preterm for risk of neurobehavioural disorders like attention deficit 
      hyperactivity disorder (ADHD) to understand the effect of altered BDNF at birth 
      on neurodevelopment.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Dhobale, M
AU  - Dhobale M
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth University, Pune 411 043, India.
FAU - Mehendale, S
AU  - Mehendale S
FAU - Pisal, H
AU  - Pisal H
FAU - D'Souza, V
AU  - D'Souza V
FAU - Joshi, S
AU  - Joshi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120426
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adult
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Docosahexaenoic Acids/metabolism
MH  - Female
MH  - Fetal Blood/metabolism
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Receptor, trkB/*metabolism
MH  - Young Adult
EDAT- 2012/05/01 06:00
MHDA- 2012/10/18 06:00
CRDT- 2012/05/01 06:00
PHST- 2012/01/09 00:00 [received]
PHST- 2012/03/29 00:00 [revised]
PHST- 2012/04/03 00:00 [accepted]
PHST- 2012/05/01 06:00 [entrez]
PHST- 2012/05/01 06:00 [pubmed]
PHST- 2012/10/18 06:00 [medline]
AID - S0306-4522(12)00327-2 [pii]
AID - 10.1016/j.neuroscience.2012.04.016 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Aug 2;216:31-7. doi: 10.1016/j.neuroscience.2012.04.016. Epub 
      2012 Apr 26.