PMID- 22542952
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20221207
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 200
IP  - 2-3
DP  - 2012 Dec 30
TI  - Interaction effect between the BDNF Val66Met polymorphism and parental rearing 
      for interpersonal sensitivity in healthy subjects.
PG  - 945-8
LID - S0165-1781(12)00123-0 [pii]
LID - 10.1016/j.psychres.2012.03.014 [doi]
AB  - Interpersonal sensitivity is defined as undue and excessive awareness of, and 
      sensitivity to, the behaviour and feelings of others and is one of the vulnerable 
      factors to depression. In a twin study, it was suggested that this personality 
      trait was characterised by both genetic and environmental factors. In the present 
      study, we examined the effects of the brain-derived neurotrophic factor (BDNF) 
      Val66Met polymorphism and parental rearing on interpersonal sensitivity in 725 
      healthy Japanese subjects. Assessment of interpersonal sensitivity was performed 
      by the Japanese version of the Interpersonal Sensitivity Measure (IPSM). 
      Perceived parental rearing was assessed by the Parental Bonding Instrument (PBI), 
      which consists of the care and protection factors. The BDNF polymorphism was 
      detected by the polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP) method. There was no main effect of the BDNF genotype on 
      the IPSM score, while the PBI factors except maternal care had significant main 
      effect on the IPSM score. There was significant interaction effect between the 
      BDNF genotype and maternal care of the PBI on the IPSM score. Post-hoc analysis 
      of simple slopes showed that the negative relationship between the IPSM score and 
      maternal care was strongest and significant in the Met/Met genotype group, 
      intermediate in the Val/Met genotype group and weakest in the Val/Val genotype 
      group. The present study suggests that the interaction between the BDNF Val66Met 
      polymorphism and parental rearing, especially maternal care, influences 
      interpersonal sensitivity in healthy subjects.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Suzuki, Akihito
AU  - Suzuki A
AD  - Department of Psychiatry, Yamagata University School of Medicine, Yamagata, 
      Japan. suzukiakihito@hotmail.com
FAU - Matsumoto, Yoshihiko
AU  - Matsumoto Y
FAU - Shibuya, Naoshi
AU  - Shibuya N
FAU - Ryoichi, Sadahiro
AU  - Ryoichi S
FAU - Kamata, Mitsuhiro
AU  - Kamata M
FAU - Enokido, Masanori
AU  - Enokido M
FAU - Goto, Kaoru
AU  - Goto K
FAU - Otani, Koichi
AU  - Otani K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120428
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - *Interpersonal Relations
MH  - Japan
MH  - Male
MH  - Maternal Behavior
MH  - Middle Aged
MH  - *Object Attachment
MH  - *Parenting
MH  - Parents
MH  - *Polymorphism, Single Nucleotide
EDAT- 2012/05/01 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/05/01 06:00
PHST- 2011/05/17 00:00 [received]
PHST- 2011/10/18 00:00 [revised]
PHST- 2012/03/15 00:00 [accepted]
PHST- 2012/05/01 06:00 [entrez]
PHST- 2012/05/01 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - S0165-1781(12)00123-0 [pii]
AID - 10.1016/j.psychres.2012.03.014 [doi]
PST - ppublish
SO  - Psychiatry Res. 2012 Dec 30;200(2-3):945-8. doi: 10.1016/j.psychres.2012.03.014. 
      Epub 2012 Apr 28.