PMID- 22544416
OWN - NLM
STAT- MEDLINE
DCOM- 20140407
LR  - 20220317
IS  - 1573-2649 (Electronic)
IS  - 0962-9343 (Linking)
VI  - 22
IP  - 3
DP  - 2013 Apr
TI  - A descriptive analysis of quality of life using patient-reported measures in 
      major depressive disorder in a naturalistic outpatient setting.
PG  - 585-96
LID - 10.1007/s11136-012-0187-6 [doi]
AB  - PURPOSE: Major depressive disorder (MDD) negatively impacts different aspects of 
      an individual's life leading to grave impairments in quality of life (QOL). We 
      performed a detailed analysis of the interaction between depressive symptom 
      severity, functioning, and QOL in outpatients with MDD in order to better 
      understand QOL impairments in MDD. METHODS: This cross-sectional study was 
      conducted with 319 consecutive outpatients seeking treatment for DSM-IV-diagnosed 
      MDD at an urban hospital-based outpatient clinic from 2005 to 2008 as part of the 
      Cedars-Sinai Psychiatric Treatment Outcome Registry, a prospective cohort study 
      of clinical, functioning, and patient-reported QOL outcomes in psychiatric 
      disorders using a measurement-based care model. This model utilizes the following 
      measures: (a) Depressive symptom severity: Quick Inventory of Depressive 
      Symptomatology-Self Report (QIDS-SR); (b) Functioning measures: Global Assessment 
      of Functioning (GAF), Sheehan Disability Scale (SDS), Work and Social Adjustment 
      Scale, and the Endicott Work Productivity Scale; and (c) Quality of Life measure: 
      Quality of Life, Enjoyment, and Satisfaction Questionnaire-Short Form (Q-LES-Q). 
      RESULTS: QOL is significantly impaired in MDD, with a mean Q-LES-Q score for this 
      study population of 39.8 % (SD = 16.9), whereas the community norm average is 
      78.3 %. Regression modeling suggested that depressive symptom severity, 
      functioning/disability, and age all significantly contributed to QOL. QIDS-SR 
      (measuring depressive symptom severity), GAF, and SDS (measuring 
      functioning/disability) scores accounted for 48.1, 17.4, and 13.3 % (semi-partial 
      correlation values) of the variance in Q-LES-Q, respectively. CONCLUSIONS: Our 
      results show that impairment of QOL increases in a monotonic fashion with 
      depressive symptom severity; however, depression symptom severity only accounted 
      for 48.1 % of the QOL variance in our patient population. Furthermore, QOL is 
      uniquely associated with measures of Functioning. We believe these results 
      demonstrate the need to utilize not only Symptom Severity scales, but also 
      Functioning and Quality of Life measures in MDD assessment, treatment, and 
      research.
FAU - Ishak, Waguih William
AU  - Ishak WW
AD  - Cedars-Sinai Medical Center, 8730 Alden Drive, Thalians W-157, Los Angeles, CA 
      90048, USA. Waguih.Ishak@cshs.org
FAU - Balayan, Konstantin
AU  - Balayan K
FAU - Bresee, Catherine
AU  - Bresee C
FAU - Greenberg, Jared Matt
AU  - Greenberg JM
FAU - Fakhry, Hala
AU  - Fakhry H
FAU - Christensen, Scott
AU  - Christensen S
FAU - Rapaport, Mark Hyman
AU  - Rapaport MH
LA  - eng
GR  - MH073765/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120429
PL  - Netherlands
TA  - Qual Life Res
JT  - Quality of life research : an international journal of quality of life aspects of 
      treatment, care and rehabilitation
JID - 9210257
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Depressive Disorder, Major/diagnosis/drug therapy/*psychology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/*methods
MH  - Outpatients/*psychology
MH  - *Patient Satisfaction
MH  - Personality Inventory
MH  - Psychiatric Status Rating Scales
MH  - Quality of Life/*psychology
MH  - Self Report
MH  - Severity of Illness Index
MH  - Sickness Impact Profile
MH  - *Surveys and Questionnaires
MH  - Urban Population
EDAT- 2012/05/01 06:00
MHDA- 2014/04/08 06:00
CRDT- 2012/05/01 06:00
PHST- 2012/04/07 00:00 [accepted]
PHST- 2012/05/01 06:00 [entrez]
PHST- 2012/05/01 06:00 [pubmed]
PHST- 2014/04/08 06:00 [medline]
AID - 10.1007/s11136-012-0187-6 [doi]
PST - ppublish
SO  - Qual Life Res. 2013 Apr;22(3):585-96. doi: 10.1007/s11136-012-0187-6. Epub 2012 
      Apr 29.