PMID- 22544701
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20210202
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 119
IP  - 23
DP  - 2012 Jun 7
TI  - MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated 
      chemokine/cytokine gene transcription within niche cells.
PG  - 5405-16
LID - 10.1182/blood-2011-11-390849 [doi]
AB  - HSC fate decisions are regulated by cell-intrinsic and cell-extrinsic cues. The 
      latter cues are derived from the BM niche. Membrane-type 1 matrix 
      metalloproteinase (MT1-MMP), which is best known for its proteolytic role in 
      pericellular matrix remodeling, is highly expressed in HSCs and stromal/niche 
      cells. We found that, in MT1-MMP(-/-) mice, in addition to a stem cell defect, 
      the transcription and release of kit ligand (KitL), stromal cell-derived factor-1 
      (SDF-1/CXCL12), erythropoietin (Epo), and IL-7 was impaired, resulting in a 
      trilineage hematopoietic differentiation block, while addition of exogenous KitL 
      and SDF-1 restored hematopoiesis. Further mechanistic studies revealed that 
      MT1-MMP activates the hypoxia-inducible factor-1 (HIF-1) pathway via factor 
      inhibiting HIF-1 (FIH-1) within niche cells, thereby inducing the transcription 
      of HIF-responsive genes, which induce terminal hematopoietic differentiation. 
      Thus, MT1-MMP in niche cells regulates postnatal hematopoiesis, by modulating 
      hematopoietic HIF-dependent niche factors that are critical for terminal 
      differentiation and migration.
FAU - Nishida, Chiemi
AU  - Nishida C
AD  - Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical 
      Science, University of Tokyo, Tokyo, Japan.
FAU - Kusubata, Kaori
AU  - Kusubata K
FAU - Tashiro, Yoshihiko
AU  - Tashiro Y
FAU - Gritli, Ismael
AU  - Gritli I
FAU - Sato, Aki
AU  - Sato A
FAU - Ohki-Koizumi, Makiko
AU  - Ohki-Koizumi M
FAU - Morita, Yohei
AU  - Morita Y
FAU - Nagano, Makoto
AU  - Nagano M
FAU - Sakamoto, Takeharu
AU  - Sakamoto T
FAU - Koshikawa, Naohiko
AU  - Koshikawa N
FAU - Kuchimaru, Takahiro
AU  - Kuchimaru T
FAU - Kizaka-Kondoh, Shinae
AU  - Kizaka-Kondoh S
FAU - Seiki, Motoharu
AU  - Seiki M
FAU - Nakauchi, Hiromitsu
AU  - Nakauchi H
FAU - Heissig, Beate
AU  - Heissig B
FAU - Hattori, Koichi
AU  - Hattori K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120427
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Stem Cell Factor)
RN  - EC 3.4.24.80 (Matrix Metalloproteinase 14)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/cytology/metabolism
MH  - Cell Line
MH  - Cells, Cultured
MH  - Chemokine CXCL12/metabolism
MH  - Chemokines/genetics
MH  - Cytokines/*genetics
MH  - Erythroid Cells/cytology/metabolism
MH  - Gene Deletion
MH  - *Hematopoiesis
MH  - Hematopoietic Stem Cells/*cytology/metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*metabolism
MH  - Matrix Metalloproteinase 14/genetics/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Stem Cell Factor/metabolism
MH  - Stromal Cells/cytology/metabolism
MH  - T-Lymphocytes/cytology/metabolism
MH  - *Transcriptional Activation
EDAT- 2012/05/01 06:00
MHDA- 2012/08/16 06:00
CRDT- 2012/05/01 06:00
PHST- 2012/05/01 06:00 [entrez]
PHST- 2012/05/01 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
AID - S0006-4971(20)47727-4 [pii]
AID - 10.1182/blood-2011-11-390849 [doi]
PST - ppublish
SO  - Blood. 2012 Jun 7;119(23):5405-16. doi: 10.1182/blood-2011-11-390849. Epub 2012 
      Apr 27.