PMID- 22545859
OWN - NLM
STAT- MEDLINE
DCOM- 20130619
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 53
IP  - 11
DP  - 2012 Nov
TI  - P53 deletion is independently associated with increased age and decreased 
      survival in a cohort of Chinese patients with diffuse large B-cell lymphoma.
PG  - 2182-5
LID - 10.3109/10428194.2012.686106 [doi]
AB  - The purpose of the study was to compare cytogenetic profiles and survivals 
      between elderly and non-elderly Chinese patients with diffuse large B-cell 
      lymphoma (DLBCL). We identified 50 patients with DLBCL and divided them by age 
      into elderly (>/=60 years) and non-elderly (< 60 years) groups. We detected 
      deletion of P53 or translocations in Bcl-2, Bcl-6 or c-myc genes by fluorescence 
      in situ hybridization (FISH). P53 deletion was significantly more common in 
      elderly versus non-elderly patients (62% vs. 17%, respectively, p=0.001) There 
      were no significant differences in rates of Bcl-2, Bcl-6 or c-myc gene 
      rearrangements between elderly and non-elderly patients (p>0.25 for each). Median 
      survival was significantly longer in non-elderly compared to elderly patients. 
      P53 deletion was an independent prognostic factor for decreased survival in 
      patients with DLBCL, independent of age. In conclusion, P53 deletion as detected 
      by FISH is associated with both increased age and decreased survival in Chinese 
      patients with DLBCL. This association with decreased survival is at least partly 
      independent of age. P53 deletion could serve as a prognostic factor in DLBCL 
      independent of or in combination with age.
FAU - Jia, Zhuxia
AU  - Jia Z
AD  - Department of Hematology, Nanjing Medical University, Changzhou, China.
FAU - He, Jinyuan
AU  - He J
FAU - Cen, Ling
AU  - Cen L
FAU - Han, Wenmin
AU  - Han W
FAU - Jiang, Naike
AU  - Jiang N
FAU - Yang, Jianhe
AU  - Yang J
FAU - Zhou, Min
AU  - Zhou M
LA  - eng
PT  - Journal Article
DEP - 20120521
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (TP53 protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - *Gene Deletion
MH  - Gene Rearrangement
MH  - Genes, bcl-2
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics/mortality
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Tumor Suppressor Protein p53/*genetics
EDAT- 2012/05/02 06:00
MHDA- 2013/06/20 06:00
CRDT- 2012/05/02 06:00
PHST- 2012/05/02 06:00 [entrez]
PHST- 2012/05/02 06:00 [pubmed]
PHST- 2013/06/20 06:00 [medline]
AID - 10.3109/10428194.2012.686106 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2012 Nov;53(11):2182-5. doi: 10.3109/10428194.2012.686106. Epub 
      2012 May 21.