PMID- 22546198
OWN - NLM
STAT- MEDLINE
DCOM- 20121017
LR  - 20161125
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 898
DP  - 2012 Jun 1
TI  - Simultaneous determination of pesticides, polycyclic aromatic hydrocarbons, 
      polychlorinated biphenyls and phthalate esters in human adipose tissue by gas 
      chromatography-tandem mass spectrometry.
PG  - 38-52
LID - 10.1016/j.jchromb.2012.04.012 [doi]
AB  - This paper describes a method for the simultaneous determination of 284 
      environmental contaminants, including 57 pesticides, 15 polycyclic aromatic 
      hydrocarbons (PAHs), 209 polychlorinated biphenyls (PCBs) and 3 phthalate esters 
      (PAEs), in adipose tissue samples. For the first time, a gas 
      chromatography-tandem mass spectrometry (GC-MS/MS) method following a homogenised 
      extraction using acetonitrile and purification by gel permeation chromatography 
      (GPC) was used. Various performance characteristics, such as the limit of 
      detection (LOD), limit of quantification (LOQ), linear range, recovery and 
      precision, were determined for each analyte. The LOD for most analytes was below 
      0.01 mg/kg. The recoveries and relative standard deviations (RSDs) were 
      determined by spiking untreated samples with the analytes at the LOQ, 2xLOQ and 
      4xLOQ levels. The average recovery for most pesticides was between 70% and 120% 
      and the precision values, expressed as RSD, were all below 20.4% (n=6). This 
      method may provide an efficient tool for evaluating the extent of exposure to 
      organic contaminants using human adipose tissue.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Wang, Na
AU  - Wang N
AD  - Nanjing Institute of Environmental Science, Ministry of Environmental Protection 
      of China, Nanjing 210042, China. wangna@nies.org
FAU - Kong, Deyang
AU  - Kong D
FAU - Shan, Zhengjun
AU  - Shan Z
FAU - Shi, Lili
AU  - Shi L
FAU - Cai, Daoji
AU  - Cai D
FAU - Cao, Yanzhong
AU  - Cao Y
FAU - Liu, Yongming
AU  - Liu Y
FAU - Pang, Guofang
AU  - Pang G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120415
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Pesticides)
RN  - 0 (Phthalic Acids)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adipose Tissue/*chemistry
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pesticides/*analysis
MH  - Phthalic Acids/*analysis
MH  - Polychlorinated Biphenyls/*analysis
MH  - Polycyclic Aromatic Hydrocarbons/*analysis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Swine
MH  - Tandem Mass Spectrometry
EDAT- 2012/05/02 06:00
MHDA- 2012/10/18 06:00
CRDT- 2012/05/02 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/04/03 00:00 [revised]
PHST- 2012/04/07 00:00 [accepted]
PHST- 2012/05/02 06:00 [entrez]
PHST- 2012/05/02 06:00 [pubmed]
PHST- 2012/10/18 06:00 [medline]
AID - S1570-0232(12)00226-7 [pii]
AID - 10.1016/j.jchromb.2012.04.012 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:38-52. doi: 
      10.1016/j.jchromb.2012.04.012. Epub 2012 Apr 15.