PMID- 22546227
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20220321
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 687
IP  - 1-3
DP  - 2012 Jul 15
TI  - Brain-derived neurotrophic factor expression after acute administration of 
      ethanol.
PG  - 9-13
LID - 10.1016/j.ejphar.2012.04.021 [doi]
AB  - Earlier findings suggest that, in addition to its well-known neurotrophic role, 
      brain-derived neurotrophic factor (BDNF) is also involved in the rewarding and 
      reinforcing effects of drugs of abuse. The purpose of the present study was to 
      examine the effects of acute administration of ethanol (1.25 or 2.5 g/kg i.p.) on 
      the expression profile of BDNF in the rat brain by determining the BDNF mRNA 
      expression in the frontal cortex, nucleus accumbens, amygdala, hippocampus, and 
      ventral tegmental area. Ethanol decreased BDNF mRNA levels dose-dependently in 
      the hippocampus, and after the higher ethanol dose in the frontal cortex, nucleus 
      accumbens and amygdala, while increasing them in the ventral tegmental area. 
      Furthermore, BDNF mRNA expression was found to be regulated in a temporally 
      different manner in all investigated brain areas. These data suggest that BDNF is 
      involved in the acute effects of ethanol, but separate brain areas may be 
      differentially engaged in the mediation of these effects.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Raivio, Noora
AU  - Raivio N
AD  - Department of Alcohol, Drugs and Addiction, National Institute for Health and 
      Welfare, Helsinki, Finland.
FAU - Tiraboschi, Ettore
AU  - Tiraboschi E
FAU - Saarikoski, Sirkku T
AU  - Saarikoski ST
FAU - Castren, Eero
AU  - Castren E
FAU - Kiianmaa, Kalervo
AU  - Kiianmaa K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120421
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Ethanol/*administration & dosage/blood/pharmacokinetics
MH  - Gene Expression Regulation/*drug effects
MH  - Male
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2012/05/02 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/05/02 06:00
PHST- 2012/01/27 00:00 [received]
PHST- 2012/04/13 00:00 [accepted]
PHST- 2012/05/02 06:00 [entrez]
PHST- 2012/05/02 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - S0014-2999(12)00355-X [pii]
AID - 10.1016/j.ejphar.2012.04.021 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2012 Jul 15;687(1-3):9-13. doi: 10.1016/j.ejphar.2012.04.021. 
      Epub 2012 Apr 21.