PMID- 22548207
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Print)
IS  - 2092-7355 (Linking)
VI  - 4
IP  - 3
DP  - 2012 May
TI  - The HLA-DRB1 Polymorphism is Associated With Atopic Dermatitis, but not Egg 
      Allergy in Korean Children.
PG  - 143-9
LID - 10.4168/aair.2012.4.3.143 [doi]
AB  - PURPOSE: We investigated whether particular HLA-DRB1 polymorphisms contribute to 
      egg allergy development in Korean children with atopic dermatitis (AD). METHODS: 
      HLA-DRB1 alleles were determined by PCR-sequence-specific oligonucleotide (SSO) 
      and PCR-single-strand conformation polymorphism (SSCP) methods in 185 patients 
      with AD and 109 normal control (NC) subjects. AD patients were divided into two 
      groups: 1) AD with egg allergy, consisting of 96 patients with egg allergies as 
      determined by egg-specific immunoglobulin E (IgE) reactivity; and 2) AD without 
      egg allergy, consisting of 89 patients without egg allergies. HLA-DRB1 alleles 
      were classified into functional groups (A, De, Dr, E, Q, R, a). HLA-DRB1 
      phenotype and functional group frequencies in the AD, AD with egg allergy, and AD 
      without egg allergy groups were compared with those in the NC group. RESULTS: The 
      frequency of DRB1(*)08:02 was decreased in the AD with egg allergy group compared 
      with the AD without egg allergy group (2.1% vs. 10.1%, P=0.021), and DRB1(*)15:01 
      was increased in the AD with egg allergy group compared with the AD without egg 
      allergy group (22.9% vs. 11.2%, P=0.036). However, significance was lost after 
      Bonferroni correction. HLA-DRB1(*)11:01 had a significantly higher frequency in 
      AD patients compared with NCs (12.4% vs. 1.8%, corrected P=0.048) and was 
      regarded as a susceptibility factor associated with AD. DRB1(*)08:03 was 
      decreased in AD patients compared with NCs (10.8% vs. 19.3%, P=0.043). HLA-DRB1 
      functional group 'a', which includes DRB1(*)15:01, seemed to be associated with 
      the development of egg allergy in AD (P=0.033), but this result was not 
      significant after Bonferroni correction. CONCLUSIONS: HLA-DRB1 polymorphism is 
      not associated with egg allergy, but HLA-DRB1(*)11:01 is associated with AD in 
      Korean children.
FAU - Park, Hwayoung
AU  - Park H
AD  - Department of Pediatrics, Eulji General Hospital, Eulji University School of 
      Medicine, Seoul, Korea.
FAU - Ahn, Kangmo
AU  - Ahn K
FAU - Park, Myoung Hee
AU  - Park MH
FAU - Lee, Sang Il
AU  - Lee SI
LA  - eng
PT  - Journal Article
DEP - 20120307
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC3328731
OTO - NOTNLM
OT  - Egg
OT  - HLA-DRB1
OT  - Korean
OT  - atopic dermatitis
OT  - children
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2012/05/02 06:00
MHDA- 2012/05/02 06:01
PMCR- 2012/05/01
CRDT- 2012/05/02 06:00
PHST- 2011/12/01 00:00 [received]
PHST- 2011/12/22 00:00 [accepted]
PHST- 2012/05/02 06:00 [entrez]
PHST- 2012/05/02 06:00 [pubmed]
PHST- 2012/05/02 06:01 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - 10.4168/aair.2012.4.3.143 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2012 May;4(3):143-9. doi: 10.4168/aair.2012.4.3.143. 
      Epub 2012 Mar 7.