PMID- 22548384
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20220311
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 35
IP  - 7
DP  - 2012 Jul
TI  - Selection of patient for cardiac resynchronization therapy: role of QT corrected 
      dispersion.
PG  - 850-5
LID - 10.1111/j.1540-8159.2012.03402.x [doi]
AB  - AIMS: About 30 to 50% of patients undergoing cardiac resynchronization therapy 
      (CRT) may not show clinical or echocardiographic improvement, despite fulfilling 
      guidelines recommendations for CRT. For this reason, we need a more accurate 
      method to assess CRT eligibility. The aims of this study were to verify, on a 
      12-month follow-up, the usefulness of QT corrected dispersion (QTcD) in a 
      patient's selection for CRT. METHODS: We stratified 53 patients who underwent 
      CRT, into two groups based on the estimation of QTcD, that is, QTcD > 60 ms and 
      QTcD </= 60 ms. In all patients were performed New York Heart Association (NYHA) 
      class determination, six-minute walking test, QtcD, and QRS measurements, and 
      complete echocardiographic assessment at 1, 3, 6, and 12 months after 
      implantation. RESULTS: At baseline, there were no significant differences in 
      clinical, echocardiographic, and electrocardiographic parameters duration between 
      two groups. At 12-month follow-up between the two groups, there were significant 
      differences in NYHA (1.2 +/- 0.4 vs 2 +/- 0.6; P < 0.01), six-minute walking distance 
      (422 +/- 68 vs 364 +/- 68; P < 0.01), left ventricular (LV) ejection fraction (34 +/- 
      7% vs 28 +/- 6%; P < 0.01), LV end-diastolic diameter (57 +/- 7 vs 63 +/- 8; P < 0.01), 
      and LV intraventricular dyssynchrony (24 +/- 14 vs 39 +/- 23; P < 0.01). CONCLUSION: 
      This study suggests that QTc dispersion in addition to QRS duration could improve 
      the sensitivity of electrocardiogram in a patient's selection for CRT.
CI  - (c)2012, The Authors. Journal compilation (c)2012 Wiley Periodicals, Inc.
FAU - Timineri, Salvatore
AU  - Timineri S
AD  - Electrophysiology Unit, Cardiology Department, Ferrarotto Hospital, University of 
      Catania, Catania, Italy. salvotimineri@hotmail.it
FAU - Mule, Massimiliano
AU  - Mule M
FAU - Puzzangara, Euglena
AU  - Puzzangara E
FAU - Santangelo, Gloria
AU  - Santangelo G
FAU - Dugo, Daniela
AU  - Dugo D
FAU - Schillaci, Vincenzo
AU  - Schillaci V
FAU - Di Grazia, Angelo
AU  - Di Grazia A
FAU - Liotta, Caudio
AU  - Liotta C
FAU - Scandura, Salvatore
AU  - Scandura S
FAU - Tempio, Donatella
AU  - Tempio D
FAU - Tamburino, Corrado
AU  - Tamburino C
FAU - Calvi, Valeria
AU  - Calvi V
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20120501
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - *Cardiac Resynchronization Therapy
MH  - Electrocardiography/*methods
MH  - Female
MH  - Heart Failure/complications/*diagnosis/*prevention & control
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Selection
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Ventricular Dysfunction, Left/complications/*diagnosis/*prevention & control
EDAT- 2012/05/03 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/03 06:00
PHST- 2012/05/03 06:00 [entrez]
PHST- 2012/05/03 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1540-8159.2012.03402.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2012 Jul;35(7):850-5. doi: 
      10.1111/j.1540-8159.2012.03402.x. Epub 2012 May 1.