PMID- 22548651
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20211021
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1264
IP  - 1
DP  - 2012 Aug
TI  - Brain-derived neurotrophic factor as a regulator of systemic and brain energy 
      metabolism and cardiovascular health.
PG  - 49-63
LID - 10.1111/j.1749-6632.2012.06525.x [doi]
AB  - Overweight sedentary individuals are at increased risk for cardiovascular 
      disease, diabetes, and some neurological disorders. Beneficial effects of dietary 
      energy restriction (DER) and exercise on brain structural plasticity and 
      behaviors have been demonstrated in animal models of aging and acute (stroke and 
      trauma) and chronic (Alzheimer's and Parkinson's diseases) neurological 
      disorders. The findings described later, and evolutionary considerations, suggest 
      brain-derived neurotrophic factor (BDNF) plays a critical role in the integration 
      and optimization of behavioral and metabolic responses to environments with 
      limited energy resources and intense competition. In particular, BDNF signaling 
      mediates adaptive responses of the central, autonomic, and peripheral nervous 
      systems from exercise and DER. In the hypothalamus, BDNF inhibits food intake and 
      increases energy expenditure. By promoting synaptic plasticity and neurogenesis 
      in the hippocampus, BDNF mediates exercise- and DER-induced improvements in 
      cognitive function and neuroprotection. DER improves cardiovascular stress 
      adaptation by a mechanism involving enhancement of brainstem cholinergic 
      activity. Collectively, findings reviewed in this paper provide a rationale for 
      targeting BDNF signaling for novel therapeutic interventions in a range of 
      metabolic and neurological disorders.
CI  - (c) 2012 New York Academy of Sciences. No claim to original U.S. Government works.
FAU - Rothman, Sarah M
AU  - Rothman SM
AD  - Laboratory of Neurosciences, National Institute on Aging Intramural Research 
      Program, National Institutes of Health, Baltimore, Maryland 21224, USA. 
      rothmansm@mail.nih.gov
FAU - Griffioen, Kathleen J
AU  - Griffioen KJ
FAU - Wan, Ruiqian
AU  - Wan R
FAU - Mattson, Mark P
AU  - Mattson MP
LA  - eng
GR  - Z99 AG999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20120430
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Autonomic Nervous System/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Caloric Restriction
MH  - Cardiovascular Diseases/*metabolism
MH  - Central Nervous System/*metabolism
MH  - Cognition
MH  - Eating
MH  - *Energy Metabolism
MH  - Exercise
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Hypothalamus/metabolism
MH  - Mice
MH  - Neuronal Plasticity
MH  - Obesity
PMC - PMC3411899
MID - NIHMS363138
EDAT- 2012/05/03 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/05/03 06:00
PHST- 2012/05/03 06:00 [entrez]
PHST- 2012/05/03 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
AID - 10.1111/j.1749-6632.2012.06525.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2012 Aug;1264(1):49-63. doi: 10.1111/j.1749-6632.2012.06525.x. 
      Epub 2012 Apr 30.