PMID- 22548711
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20221207
IS  - 1601-183X (Electronic)
IS  - 1601-183X (Linking)
VI  - 11
IP  - 5
DP  - 2012 Jul
TI  - Association of BDNF gene polymorphism with bipolar disorders in Han Chinese 
      population.
PG  - 524-8
LID - 10.1111/j.1601-183X.2012.00797.x [doi]
AB  - Recent data suggest that brain-derived neurotrophic factor (BDNF) plays an 
      essential role in neuronal plasticity and etiology of bipolar disorders (BPD). 
      However, results from different studies have been inconsistent. In present study, 
      342 patients who met DSM-IV (Diagnostic and Statistical Manual of Mental 
      Disorders, 4th Edition) criteria for bipolar disorders type I (BPD-I) or type II 
      (BPD-II) and 386 matched health controls were enrolled, and TaqMan((R)) SNP 
      Genotyping Assays (Applied Biosystems, Foster City, CA, USA) were applied to 
      detect the functional polymorphism rs6265 (Val66Met) of BDNF gene. Treatment 
      response to lithium and valproate was retrospectively determined. The association 
      between Val66Met polymorphism and BPD, treatment response to mood stabilizers, 
      was estimated. The genotype and allele distribution of Val66Met polymorphism 
      between BPD patients and control subjects showed significant difference 
      (genotype: chi(2) = 6.18, df = 2, P = 0.046; allele: chi(2) = 5.01, df = 1, P = 
      0.025) with Met allele as risk factor for disease susceptibility (OR = 0.79, 
      95%CI as 0.64-0.97). The post hoc analysis interestingly showed that Met allele 
      had opposite effect on the treatment response for BPD-I and BPD-II separately. 
      For BPD-I patients, the response score in Val/Val group was significantly lower 
      than that in Met allele carriers (t = -2.27, df = 144, P = 0.025); for BPD-II 
      patients, the response score in Val/Val group was significantly higher than that 
      in Met allele carriers (t = 2.33, df = 26, P = 0.028). Although these results 
      should be interpreted with caution because of the limited sample for Val/Val 
      genotype in BPD-II patients (N = 5), these findings strengthen the hypothesis 
      that BDNF pathway gets involved in the etiology and pharmacology of BPD and 
      suggest the differences between BPD-I and BPD-II.
CI  - (c) 2012 The Authors. Genes, Brain and Behavior (c) 2012 Blackwell Publishing Ltd and 
      International Behavioural and Neural Genetics Society.
FAU - Wang, Z
AU  - Wang Z
AD  - Shanghai Mental Health Center, Department of Psychiatry, Shanghai Jiao Tong 
      University School of Medicine, China.
FAU - Li, Z
AU  - Li Z
FAU - Chen, J
AU  - Chen J
FAU - Huang, J
AU  - Huang J
FAU - Yuan, C
AU  - Yuan C
FAU - Hong, W
AU  - Hong W
FAU - Yu, S
AU  - Yu S
FAU - Fang, Y
AU  - Fang Y
LA  - eng
PT  - Journal Article
DEP - 20120504
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/*genetics
MH  - Bipolar Disorder/diagnosis/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - China
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2012/05/03 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/03 06:00
PHST- 2012/05/03 06:00 [entrez]
PHST- 2012/05/03 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1601-183X.2012.00797.x [doi]
PST - ppublish
SO  - Genes Brain Behav. 2012 Jul;11(5):524-8. doi: 10.1111/j.1601-183X.2012.00797.x. 
      Epub 2012 May 4.