PMID- 22548843
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1755-8166 (Electronic)
IS  - 1755-8166 (Linking)
VI  - 5
IP  - 1
DP  - 2012 May 1
TI  - A novel five-way translocation t(7;11;9;22;9)(q22;q13;q34;q11.2;q34) involving Ph 
      chromosome in a patient of chronic myeloid leukemia: a case report.
PG  - 20
LID - 10.1186/1755-8166-5-20 [doi]
AB  - About 5-10 % of chronic myelogenous leukemia (CML) patients show variant 
      Philadelphia (Ph) translocations. The formation mechanisms and clinical 
      significance of variant Ph translocations remain unclear. We report a CML case 
      with a novel five-way complex translocation. Although the result of initial 
      G-banding was 46,XY,t(7;11;9)(q22;q13;q34),t(9;22)(q34;q11.2), fluorescence in 
      situ hybridization (FISH) demonstrated t(7;11;9;22;9)(q22;q13;q34;q11.2;q34) 
      consisting of sequential rearrangements involving five chromosomes. The patient 
      was successfully treated by imatinib and obtained a major molecular response. To 
      our knowledge, this is the tenth CML case with a complicated Ph translocation 
      involving five chromosomes and the third one treated by imatinib. Good response 
      with imatinib therapy suggested that a single-event rearrangement was involved in 
      the chromosomal changes.
FAU - Yokota, Sho
AU  - Yokota S
AD  - Department of Hematology, Saitama Medical University Hospital, 38 Moro-Hongo, 
      Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan. ynakam@saitama-med.ac.jp.
FAU - Nakamura, Yuichi
AU  - Nakamura Y
FAU - Bessho, Masami
AU  - Bessho M
LA  - eng
PT  - Journal Article
DEP - 20120501
PL  - England
TA  - Mol Cytogenet
JT  - Molecular cytogenetics
JID - 101317942
PMC - PMC3407734
EDAT- 2012/05/03 06:00
MHDA- 2012/05/03 06:01
PMCR- 2012/05/01
CRDT- 2012/05/03 06:00
PHST- 2011/12/19 00:00 [received]
PHST- 2012/05/01 00:00 [accepted]
PHST- 2012/05/03 06:00 [entrez]
PHST- 2012/05/03 06:00 [pubmed]
PHST- 2012/05/03 06:01 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - 1755-8166-5-20 [pii]
AID - 10.1186/1755-8166-5-20 [doi]
PST - epublish
SO  - Mol Cytogenet. 2012 May 1;5(1):20. doi: 10.1186/1755-8166-5-20.