PMID- 22549618
OWN - NLM
STAT- MEDLINE
DCOM- 20121005
LR  - 20190221
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 122
IP  - 8
DP  - 2012 Aug
TI  - Immunohistochemical expression patterns of the HER4 receptors in normal mucosa 
      and in laryngeal squamous cell carcinomas: antioncogenic significance of the HER4 
      protein in laryngeal squamous cell carcinoma.
PG  - 1724-33
LID - 10.1002/lary.23311 [doi]
AB  - OBJECTIVES/HYPOTHESIS: The prognosis for laryngeal squamous cell carcinoma (LSCC) 
      has not shown any improvement in the last 30 years because of inadequate 
      prognostic stratification. Therefore, the detection of reliable molecular markers 
      may have a significant impact on clinical practice. As promising data regarding 
      HER1/EGFR have been published, the purpose of the present study was to elucidate 
      the role of the other receptors of the HER family. STUDY DESIGN: Retrospective. 
      METHODS: We used quantitative immunohistochemistry to evaluate the expression 
      pattern of the HER4 receptors cytokeratin (CK)-14, CK-17, and proliferating cell 
      nuclear antigen in 67 LSCCs and assessed correlations with various prognostic 
      parameters. RESULTS: HER1 levels inversely correlated with those of HER2-4. The 
      negative prognostic value of HER1 was confirmed, and a protective role for HER2-4 
      was found. Specifically, the overexpression of HER4 and its nuclear localization 
      are protective and are associated with a better prognosis. CONCLUSIONS: 
      Semiquantitative evaluation of HER2-4 provides predictive information that can be 
      combined with HER1 expression data for molecular characterization of LSCC. The 
      pattern of localization of HER4 is an easily evaluable qualitative parameter with 
      a clear correlation with prognosis. The immunohistochemical methods described in 
      this article are reliable, reproducible, and potentially translatable to clinical 
      practice.
CI  - Copyright (c) 2012 The American Laryngological, Rhinological, and Otological 
      Society, Inc.
FAU - Bussu, Francesco
AU  - Bussu F
AD  - Department of Otolaryngology, Catholic University of the Sacred Heart, Rome. 
      francescobussu@yahoo.it
FAU - Ranelletti, Franco O
AU  - Ranelletti FO
FAU - Gessi, Marco
AU  - Gessi M
FAU - Graziani, Cristina
AU  - Graziani C
FAU - Lanza, Paola
AU  - Lanza P
FAU - Lauriola, Libero
AU  - Lauriola L
FAU - Paludetti, Gaetano
AU  - Paludetti G
FAU - Almadori, Giovanni
AU  - Almadori G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120501
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Keratin-14)
RN  - 0 (Keratin-17)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ERBB4 protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, ErbB-4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*pathology/therapy
MH  - Chemoradiotherapy, Adjuvant
MH  - Combined Modality Therapy
MH  - ErbB Receptors/*analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Head and Neck Neoplasms/*pathology/therapy
MH  - Humans
MH  - *Immunoenzyme Techniques
MH  - Keratin-14/analysis
MH  - Keratin-17/analysis
MH  - Laryngeal Mucosa/pathology
MH  - Laryngeal Neoplasms/*pathology/therapy
MH  - Laryngectomy
MH  - Larynx/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neck Dissection
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proliferating Cell Nuclear Antigen/analysis
MH  - Receptor, ErbB-4
MH  - Sensitivity and Specificity
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2012/05/03 06:00
MHDA- 2012/10/06 06:00
CRDT- 2012/05/03 06:00
PHST- 2011/10/12 00:00 [received]
PHST- 2012/01/21 00:00 [revised]
PHST- 2012/02/27 00:00 [accepted]
PHST- 2012/05/03 06:00 [entrez]
PHST- 2012/05/03 06:00 [pubmed]
PHST- 2012/10/06 06:00 [medline]
AID - 10.1002/lary.23311 [doi]
PST - ppublish
SO  - Laryngoscope. 2012 Aug;122(8):1724-33. doi: 10.1002/lary.23311. Epub 2012 May 1.