PMID- 22550695
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20220317
IS  - 1077-3525 (Print)
IS  - 1077-3525 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Jan-Mar
TI  - Bronchiolitis obliterans and consumer exposure to butter-flavored microwave 
      popcorn: a case series.
PG  - 29-42
AB  - Respiratory exposure to diacetyl and diacetyl-containing flavorings used in 
      butter-flavored microwave popcorn (BFMP) causes lung disease, including 
      bronchiolitis obliterans (BO), in flavorings and popcorn manufacturing workers. 
      However, there are no published reports of lung disease among BFMP consumers. We 
      present a case series of three BFMP consumers with biopsy-confirmed BO. We review 
      data relating to consumer exposures, estimate case exposures, and compare them to 
      diacetyl-containing flavoring-exposed manufacturing workers with lung disease. 
      These consumer cases' exposure levels are comparable to those that caused disease 
      in workers. We were unable to identify any other exposures or diseases known or 
      suspected to cause BO in these cases. BFMP poses a significant respiratory risk 
      to consumers. Some manufacturers have substituted diacetyl with other 
      alpha-diketones that are likely to pose a similar risk. Simple consumer practices 
      such as cooling the popcorn bag would eliminate the risk of severe lung disease.
FAU - Egilman, David S
AU  - Egilman DS
AD  - Department of Family Medicine, Brown University, Providence, Rhode Island, USA. 
      degilman@egilman.com
FAU - Schilling, John Henry
AU  - Schilling JH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J Occup Environ Health
JT  - International journal of occupational and environmental health
JID - 9505217
RN  - 0 (Flavoring Agents)
RN  - K324J5K4HM (Diacetyl)
SB  - IM
MH  - Bronchiolitis Obliterans/*chemically induced/pathology
MH  - Consumer Product Safety/standards
MH  - Diacetyl/*poisoning
MH  - Female
MH  - Flavoring Agents/*poisoning
MH  - Food-Processing Industry/standards
MH  - Humans
MH  - Inhalation Exposure/adverse effects
MH  - Male
MH  - Microwaves
MH  - Middle Aged
MH  - United States
MH  - Zea mays
EDAT- 2012/05/04 06:00
MHDA- 2012/06/01 06:00
CRDT- 2012/05/04 06:00
PHST- 2012/05/04 06:00 [entrez]
PHST- 2012/05/04 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 10.1179/1077352512Z.0000000005 [doi]
PST - ppublish
SO  - Int J Occup Environ Health. 2012 Jan-Mar;18(1):29-42. doi: 
      10.1179/1077352512Z.0000000005.