PMID- 22551661
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20151119
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 46
IP  - 7
DP  - 2012 Jul
TI  - Childhood trauma and platelet brain-derived neurotrophic factor (BDNF) after a 
      three month follow-up in patients with major depressive disorder.
PG  - 966-72
LID - 10.1016/j.jpsychires.2012.04.006 [doi]
AB  - A large amount of brain-derived neurotrophic factor (BDNF) is stored in the human 
      platelets and only small amounts of it circulate in the plasma. However, a few 
      studies have focused on platelet BDNF in patients with major depressive disorder 
      (MDD) and childhood trauma. Our study population consisted of 105 MDD patients 
      and 50 healthy controls. We used the mini-international neuropsychiatric 
      interview (M.I.N.I.), the early trauma inventory self report-short form 
      (ETISR-SF), as well as measured serum, plasma, and platelet BDNF at baseline, 1 
      month, and 3 month periods. There was a significant association between childhood 
      trauma and platelet BDNF at baseline, 1 month, and 3 months, after adjusting for 
      age, gender, education, body mass index, severity of depression, anxiety, alcohol 
      consumption, and current stress. Conversely, plasma and serum BDNF did not have a 
      significant association with childhood trauma. MDD patients revealed 
      significantly higher levels of platelet BDNF in those with childhood trauma than 
      in those without (t = 2.4, p = 0.018), and platelet BDNF was significantly higher 
      in cases with sexual abuse on post-hoc analysis (p = 0.042). However, no 
      significant differences were found in healthy controls, according to whether or 
      not they had experienced childhood trauma. Platelet BDNF showed a significant 
      correlation with severity of childhood trauma at baseline (r = 0.25, p = 0.012) 
      and at 3 months (r = 0.38, p = 0.003) in MDD. In conclusion, platelet BDNF was 
      significantly higher in MDD patients with childhood trauma than in those without, 
      and it was correlated with severity of trauma.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Jeon, Hong Jin
AU  - Jeon HJ
AD  - Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine, #50 Irwon-dong, Gangnam-gu, Seoul 135-710, 
      Republic of Korea.
FAU - Kang, Eun-Suk
AU  - Kang ES
FAU - Lee, Eun Ho
AU  - Lee EH
FAU - Jeong, Eu-Gene
AU  - Jeong EG
FAU - Jeon, Ju-Ri
AU  - Jeon JR
FAU - Mischoulon, David
AU  - Mischoulon D
FAU - Lee, Dongsoo
AU  - Lee D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120501
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Adult Survivors of Child Abuse/*psychology
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Self Report
MH  - Surveys and Questionnaires
MH  - Wounds and Injuries/*blood/epidemiology
EDAT- 2012/05/04 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/05/04 06:00
PHST- 2012/02/05 00:00 [received]
PHST- 2012/04/04 00:00 [revised]
PHST- 2012/04/05 00:00 [accepted]
PHST- 2012/05/04 06:00 [entrez]
PHST- 2012/05/04 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S0022-3956(12)00120-3 [pii]
AID - 10.1016/j.jpsychires.2012.04.006 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2012 Jul;46(7):966-72. doi: 10.1016/j.jpsychires.2012.04.006. 
      Epub 2012 May 1.