PMID- 22551918
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20211021
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 31
IP  - 3
DP  - 2012 May-Jun
TI  - Identification of t(1;19)(q12;p13) and ploidy changes in an ependymosarcoma: a 
      cytogenetic evaluation.
PG  - 142-5
AB  - Gliosarcoma, a recognized subtype of glioblastoma, is a biphasic tumor exhibiting 
      distinct glial and sarcomatous components. Ependymosarcomas are rarer, biphasic 
      ependymal tumors exhibiting sarcomatous change. Genetic abnormalities associated 
      with this curious phenotype are not well understood. We are presenting the first 
      karyotype of ependymosarcoma with identification of a clonal t(1;19)(q12;p13). 
      Fluorescence in situ hybridization (FISH) was performed with a probe set 
      targeting 1q23 and 19p13.3. Although the tumor did not show evidence of 
      t(1;19)(q23;p13.3) by FISH, increased ploidy was a feature of the sarcomatous 
      component. On clinical followup the patient is doing well without evidence of 
      recurrence 55 months after initial resection, and postoperative treatment with 
      irradiation and temozolomide. The significance of the genetic alterations we 
      describe associated with sarcomatoid change in ependymal neoplasms, and 
      ultimately their prognostic relevance, merits further study.
FAU - Tabbarah, Abeer Z
AU  - Tabbarah AZ
AD  - Department of Pathology, George Washington University, Washington, D.C., USA.
FAU - Carlson, Austin W
AU  - Carlson AW
FAU - Oviedo, Angelica
AU  - Oviedo A
FAU - Ketterling, Rhett P
AU  - Ketterling RP
FAU - Rodriguez, Fausto J
AU  - Rodriguez FJ
LA  - eng
GR  - P30 CA006973/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
SB  - IM
MH  - Abnormal Karyotype
MH  - Adolescent
MH  - Brain Neoplasms/genetics/pathology
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 19/*genetics
MH  - Ependymoma/*genetics/pathology
MH  - Female
MH  - Gliosarcoma/*genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - *Ploidies
PMC - PMC3657470
MID - NIHMS448282
EDAT- 2012/05/04 06:00
MHDA- 2012/07/20 06:00
PMCR- 2012/05/01
CRDT- 2012/05/04 06:00
PHST- 2012/05/04 06:00 [entrez]
PHST- 2012/05/04 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - 9473 [pii]
AID - 10.5414/np300451 [doi]
PST - ppublish
SO  - Clin Neuropathol. 2012 May-Jun;31(3):142-5. doi: 10.5414/np300451.