PMID- 22552045
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20211021
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 72
IP  - 6
DP  - 2012 Sep 15
TI  - Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism 
      contributes to developmental and estrous stage-specific expression of 
      anxiety-like behavior in female mice.
PG  - 499-504
LID - 10.1016/j.biopsych.2012.03.032 [doi]
AB  - BACKGROUND: Most anxiety and depressive disorders are twice as common in women 
      compared with men, and the sex difference in prevalence typically emerges during 
      adolescence. Hormonal changes across the menstrual cycle and during the 
      postpartum and perimenopausal periods are associated with increased risk for 
      anxiety and depression symptoms. In humans and animals, reduced brain-derived 
      neurotrophic factor (BDNF) has been associated with increased expression of 
      affective pathology. Recently, a single nucleotide polymorphism (SNP) in the BDNF 
      gene (BDNF Valine66Methionine [Val66Met]), which reduces BDNF bioavailability, 
      has been identified in humans and associated with a variety of neuropsychiatric 
      disorders. Although BDNF expression can be directly influenced by estrogen and 
      progesterone, the potential impact of the BDNF Val66Met SNP on sensitivity to 
      reproductive hormone changes remains an open question. METHODS: As a predictive 
      model, we used female mice in which the human SNP (BDNF Val66Met) was inserted 
      into the mouse BDNF gene. Using standard behavioral paradigms, we tested the 
      impact of this SNP on age and estrous-cycle-specific expression of anxiety-like 
      behaviors. RESULTS: Mice homozygous for the BDNF Val66Met SNP begin to exhibit 
      increased anxiety-like behaviors over prepubertal and early adult development, 
      show significant fluctuations in anxiety-like behaviors over the estrous cycle, 
      and, as adults, differ from wild-type mice by showing significant fluctuations in 
      anxiety-like behaviors over the estrous cycle-specifically, more anxiety-like 
      behaviors during the estrus phase. CONCLUSIONS: These findings have implications 
      regarding the potential role of this SNP in contributing to developmental and 
      reproductive hormone-dependent changes in affective disorders in humans.
CI  - Copyright (c) 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Bath, Kevin G
AU  - Bath KG
AD  - Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA.
FAU - Chuang, Jocelyn
AU  - Chuang J
FAU - Spencer-Segal, Joanna L
AU  - Spencer-Segal JL
FAU - Amso, Dima
AU  - Amso D
FAU - Altemus, Margaret
AU  - Altemus M
FAU - McEwen, Bruce S
AU  - McEwen BS
FAU - Lee, Francis S
AU  - Lee FS
LA  - eng
GR  - RC1 MH088814/MH/NIMH NIH HHS/United States
GR  - R01 NS007080/NS/NINDS NIH HHS/United States
GR  - R01 NS007080-42/NS/NINDS NIH HHS/United States
GR  - MH082528/MH/NIMH NIH HHS/United States
GR  - R01 NS052819/NS/NINDS NIH HHS/United States
GR  - MH060478/MH/NIMH NIH HHS/United States
GR  - F30 MH082528/MH/NIMH NIH HHS/United States
GR  - NS052819/NS/NINDS NIH HHS/United States
GR  - T32 GM007739/GM/NIGMS NIH HHS/United States
GR  - MH088814/MH/NIMH NIH HHS/United States
GR  - NS07080/NS/NINDS NIH HHS/United States
GR  - GM07739/GM/NIGMS NIH HHS/United States
GR  - P50 MH079513-04/MH/NIMH NIH HHS/United States
GR  - P50 MH079513/MH/NIMH NIH HHS/United States
GR  - R01 NS052819-06/NS/NINDS NIH HHS/United States
GR  - R25 MH060478/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120501
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
CIN - Biol Psychiatry. 2012 Sep 15;72(6):434-6. PMID: 22906753
MH  - Alleles
MH  - Analysis of Variance
MH  - Animals
MH  - Anxiety/*genetics
MH  - *Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Disease Models, Animal
MH  - Estrus/*genetics
MH  - Female
MH  - Mice
MH  - Mutagenesis, Insertional
MH  - *Polymorphism, Single Nucleotide
MH  - Sexual Maturation/*genetics
PMC - PMC3414635
MID - NIHMS369468
COIS- The authors report no biomedical financial interests or potential conflicts of 
      interest.
EDAT- 2012/05/04 06:00
MHDA- 2013/01/23 06:00
PMCR- 2013/09/15
CRDT- 2012/05/04 06:00
PHST- 2011/04/04 00:00 [received]
PHST- 2012/02/29 00:00 [revised]
PHST- 2012/03/15 00:00 [accepted]
PHST- 2012/05/04 06:00 [entrez]
PHST- 2012/05/04 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PHST- 2013/09/15 00:00 [pmc-release]
AID - S0006-3223(12)00311-3 [pii]
AID - 10.1016/j.biopsych.2012.03.032 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2012 Sep 15;72(6):499-504. doi: 10.1016/j.biopsych.2012.03.032. 
      Epub 2012 May 1.