PMID- 22552848
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20211210
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Jul
TI  - Chrysin attenuates allergic airway inflammation by modulating the transcription 
      factors T-bet and GATA-3 in mice.
PG  - 100-4
LID - 10.3892/mmr.2012.893 [doi]
AB  - Chrysin, a flavonoid obtained from various natural sources, has been reported to 
      possess anti-inflammatory, antitumor, antioxidant and anti-allergic activities. 
      However, its anti-inflammatory and immunoregulatory activities in asthma animal 
      models are poorly understood. In the present study, we examined the effects of 
      chrysin on airway inflammation and the possible mechanisms through which it acts 
      in a murine model of allergic asthma. BALB/c mice sensitized and challenged to 
      ovalbumin (OVA) were administered intragastrically with chrysin at a dose of 50 
      mg/kg daily. Chrysin significantly suppressed OVA-induced airway 
      hyperresponsiveness (AHR) to acetylcholine chloride (Ach). Chrysin administration 
      significantly inhibited the total inflammatory cell and eosinophil counts in 
      bronchoalveolar lavage fluid (BALF) and total immunoglobulin E (IgE) levels in 
      serum. Histological examination of lung tissue demonstrated that chrysin 
      significantly attenuated allergen-induced lung eosinophilic inflammation and 
      mucus-producing goblet cells in the airway. In addition, chrysin triggered a 
      switch of the immune response to allergens towards a T-helper type 1 (Th1) 
      profile by modulating the transcription factors T-bet and GATA-3 in allergic 
      mice. These data suggest that chrysin exhibits anti-inflammatory and 
      immunoregulatory properties and provides new insights into the 
      immunopharmacological role of chrysin in terms of its effects in a murine model 
      of asthma.
FAU - Du, Qiang
AU  - Du Q
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Nanjing 
      Medical University, Nanjing, Jiangsu 210011, PR China.
FAU - Gu, Xiaoyan
AU  - Gu X
FAU - Cai, Jiankang
AU  - Cai J
FAU - Huang, Mao
AU  - Huang M
FAU - Su, Mei
AU  - Su M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120426
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Flavonoids)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor TBX21)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3CN01F5ZJ5 (chrysin)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/*therapeutic use
MH  - Asthma/*drug therapy/immunology/*metabolism
MH  - Bronchial Hyperreactivity/drug therapy/immunology
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Flavonoids/pharmacology/*therapeutic use
MH  - GATA3 Transcription Factor/*metabolism
MH  - Immunoglobulin E/blood/immunology
MH  - Inflammation/drug therapy/immunology
MH  - Lung/drug effects/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - T-Box Domain Proteins/*metabolism
MH  - Th1 Cells/drug effects/immunology
MH  - Th2 Cells/drug effects/immunology
OTO - NOTNLM
OT  - chrysin
OT  - asthma
OT  - airway inflammation
OT  - T-bet
OT  - GATA-3
EDAT- 2012/05/04 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/05/04 06:00
PHST- 2012/01/17 00:00 [received]
PHST- 2012/04/20 00:00 [accepted]
PHST- 2012/05/04 06:00 [entrez]
PHST- 2012/05/04 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.3892/mmr.2012.893 [doi]
PST - ppublish
SO  - Mol Med Rep. 2012 Jul;6(1):100-4. doi: 10.3892/mmr.2012.893. Epub 2012 Apr 26.