PMID- 22553924
OWN - NLM
STAT- MEDLINE
DCOM- 20130415
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 53
IP  - 12
DP  - 2012 Dec
TI  - Recurrent breakpoints in 14q32.13/TCL1A region in mature B-cell neoplasms with 
      villous lymphocytes.
PG  - 2449-55
LID - 10.3109/10428194.2012.690098 [doi]
AB  - The genetic background of mature B-cell neoplasms with villous lymphocytes is 
      poorly understood. We identified a novel breakpoint region at 14q32.13 that was 
      rearranged together with IGH/14q32.33 in four cases of BRAF/V600E-negative 
      leukemia/lymphoma with villous lymphocytes carrying either 
      t(14;14)(q32.13;q32.33) (three patients) or del(14)(q32.13q32.33) (one patient). 
      The 14q32.13 breakpoints were mapped by fluorescence in situ hybridization (FISH) 
      in the region harboring the TCL1A/TCL1B/TCL6 genes, known to be affected by 
      TCRA/D-mediated t(14;14)(q11;q32)/inv(14)(q11q32) occurring in T-cell 
      leukemia/lymphoma. To identify the target of t(14;14)(q32.13; q32.33) and 
      del(14)(q32.13q32.33), quantitative real-time polymerase chain reaction (qRT-PCR) 
      analysis of 25 candidate genes located centromerically and telomerically to the 
      14q32.13 breakpoint was performed. Any of the analyzed genes was commonly 
      overexpressed in the presented cases. Of note, up-regulated transcription of 
      TCL1A was observed in two cases. In summary, we provide evidence that 
      IGH-mediated chromosomal aberrations affecting the 14q32.13/TCL1A-TCL6 region are 
      recurrent in mature B-cell neoplasms with villous lymphocytes. Despite extensive 
      qRT-PCR studies, molecular consequences of these novel aberrations remain 
      elusive.
FAU - Urbankova, Helena
AU  - Urbankova H
AD  - Center for Human Genetics, KU Leuven, Leuven, Belgium.
FAU - Baens, Mathijs
AU  - Baens M
FAU - Michaux, Lucienne
AU  - Michaux L
FAU - Tousseyn, Thomas
AU  - Tousseyn T
FAU - Rack, Katrina
AU  - Rack K
FAU - Katrincsakova, Beata
AU  - Katrincsakova B
FAU - Ferreiro, Julio Finalet
AU  - Ferreiro JF
FAU - van Loo, Peter
AU  - van Loo P
FAU - de Kelver, Wim
AU  - de Kelver W
FAU - Dierickx, Daan
AU  - Dierickx D
FAU - Demuynck, Hilde
AU  - Demuynck H
FAU - Delannoy, Andre
AU  - Delannoy A
FAU - Verschuere, Johan
AU  - Verschuere J
FAU - Jarosova, Marie
AU  - Jarosova M
FAU - de Wolf-Peeters, Chris
AU  - de Wolf-Peeters C
FAU - Vandenberghe, Peter
AU  - Vandenberghe P
FAU - Wlodarska, Iwona
AU  - Wlodarska I
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (TCL1A protein, human)
SB  - IM
MH  - Aged
MH  - B-Lymphocytes/*metabolism/pathology
MH  - *Chromosome Aberrations
MH  - Chromosome Breakpoints
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Chromosomes, Human, Pair 4/genetics
MH  - Fatal Outcome
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/genetics
MH  - Lymphoma, B-Cell/genetics
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Translocation, Genetic
EDAT- 2012/05/05 06:00
MHDA- 2013/04/16 06:00
CRDT- 2012/05/05 06:00
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2013/04/16 06:00 [medline]
AID - 10.3109/10428194.2012.690098 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2012 Dec;53(12):2449-55. doi: 10.3109/10428194.2012.690098.