PMID- 22554061
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20181201
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 23
IP  - 5
DP  - 2012 Aug
TI  - Host and environmental factors influencing respiratory secretion of pro-wheezing 
      biomarkers in preterm children.
PG  - 441-7
LID - 10.1111/j.1399-3038.2012.01269.x [doi]
AB  - Cytokines are actively secreted by the respiratory mucosa of preterm children and 
      participate in the pathogenesis of wheezing. This study aimed to identify the 
      factors that could potentially influence respiratory secretion of cytokines in 
      these children. A nasopharyngeal aspirate (NPA) was collected from 77 preterm 
      children 1 yr after birth. NPAs from 14 healthy, 1-yr-old term children were 
      collected in parallel. 27 cytokines were measured in the NPAs using a multiplex 
      assay. Multivariate stepwise regression analysis with Bonferroni correction 
      evidenced that the variable [daycare attendance] was associated with higher 
      levels of [monocyte chemoattractant protein-1 (MCP-1), IL-6, vascular endothelial 
      growth factor (VEGF), IL-1beta, IL-10, tumor necrosis factor (TNF)-alpha]; [male sex] 
      with higher levels of (MCP-1, VEGF, and IL-1beta); [smokers at home] was associated 
      with higher levels of MCP-1 (p < 0.0013). In turn, [prophylaxis with palivizumab] 
      was associated with lower levels of (IL-6, IL-7) (p < 0.0013). All these 
      mediators participate in the pathogenesis of asthma and recurrent wheezing. 
      Preterm children secreted higher levels of chemokines (interferon-gamma inducible 
      protein-10, macrophage inflammatory protein-1alpha, Eotaxin, MCP-1), growth factors 
      (platelet-derived growth factor-bb, VEGF, fibroblast growth factor-basic, 
      granulocyte macrophage colony-stimulating factor), Th1 (IL12, interferon-gamma), Th2 
      (IL-9, IL-13), Th17 (IL-6, IL-17) cytokines, and immunomodulatory mediators 
      (IL1RA and granulocyte colony-stimulating factor) than term children. In 
      conclusion, we have identified for the first time a group of individual and 
      environmental factors influencing respiratory secretion of cytokines in preterm 
      children at the long term after birth. To know these factors could help to 
      prevent the instauration of conditions linked to the appearance of chronic 
      respiratory diseases such as wheezing or asthma.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Matias, Vanesa
AU  - Matias V
AD  - Servicio de Pediatria, Hospital Clinico Universitario, SACYL, Valladolid, Spain.
FAU - San Feliciano, Laura
AU  - San Feliciano L
FAU - Fernandez, Jose E
AU  - Fernandez JE
FAU - Lapena, Santiago
AU  - Lapena S
FAU - Garrido, Estibaliz
AU  - Garrido E
FAU - Ardura, Julio
AU  - Ardura J
FAU - Soga, Maria Jose
AU  - Soga MJ
FAU - Aragon, Maria Paz
AU  - Aragon MP
FAU - Remesal, Ana
AU  - Remesal A
FAU - Benito, Francisca
AU  - Benito F
FAU - Andres, Jesus
AU  - Andres J
FAU - Centeno, Fernando
AU  - Centeno F
FAU - Marugan, Victor
AU  - Marugan V
FAU - Bachiller, Rosario
AU  - Bachiller R
FAU - Bermejo-Martin, Jesus F
AU  - Bermejo-Martin JF
LA  - eng
PT  - Journal Article
DEP - 20120503
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (IL1RN protein, human)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
SB  - IM
MH  - Asthma/*immunology
MH  - Biomarkers/metabolism
MH  - Cytokines/metabolism
MH  - Environmental Exposure/adverse effects
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature/*immunology
MH  - Intercellular Signaling Peptides and Proteins/metabolism
MH  - Interleukin 1 Receptor Antagonist Protein/metabolism
MH  - Male
MH  - Respiratory Mucosa/immunology
MH  - Respiratory Sounds/*immunology
MH  - Sex Factors
MH  - Smoking/adverse effects
MH  - Socioeconomic Factors
MH  - Spain
EDAT- 2012/05/05 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/05 06:00
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1399-3038.2012.01269.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2012 Aug;23(5):441-7. doi: 
      10.1111/j.1399-3038.2012.01269.x. Epub 2012 May 3.