PMID- 22554067
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20220408
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 53
IP  - 6
DP  - 2012 Jun
TI  - Depressive and anxiety disorders in epilepsy: do they differ in their potential 
      to worsen common antiepileptic drug-related adverse events?
PG  - 1104-8
LID - 10.1111/j.1528-1167.2012.03488.x [doi]
AB  - PURPOSE: To compare the effect of anxiety disorders, major depressive episodes 
      (MDEs), and subsyndromic depressive episodes (SSDEs) on antiepileptic drug 
      (AED)-related adverse events (AEs) in persons with epilepsy (PWE). METHODS: The 
      study included 188 consecutive PWE from five U.S. outpatient epilepsy clinics, 
      all of whom underwent structured interviews (SCID) to identify current and past 
      mood disorders and other current Axis I psychiatric diagnoses according to 
      Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text 
      Revision (DSM-IV-TR) criteria. A diagnosis of SSDE was made in patients with 
      total Beck Depression Inventory-II (BDI-II) scores >12 or the Centers of 
      Epidemiologic Studies-Depression (CES-D) > 16 (in the absence of any DSM 
      diagnosis of mood disorder. The presence and severity of AEs was measured with 
      the Adverse Event Profile (AEP). KEY FINDINGS: Compared to asymptomatic patients 
      (n = 103), the AEP scores of patients with SSDE (n = 26), MDE only (n = 10), 
      anxiety disorders only (n = 21), or mixed MDE/anxiety disorders (n = 28) were 
      significantly higher, suggesting more severe AED-related AEs. Univariate analyses 
      revealed that having persistent seizures in the last 6 months and taking 
      antidepressants was associated with more severe AEs. Post hoc analyses, however, 
      showed that these differences were accounted for by the presence of a depressive 
      and/or anxiety disorders. SIGNIFICANCE: Depressive and anxiety disorders worsen 
      AED-related AEs even when presenting as a subsyndromic type. These data suggest 
      that the presence of psychiatric comorbidities must be considered in their 
      interpretation, both in clinical practice and AED drug trials.
CI  - Wiley Periodicals, Inc. (c) 2012 International League Against Epilepsy.
FAU - Kanner, Andres M
AU  - Kanner AM
AD  - Department of Neurological Sciences, Rush Medical College, Chicago, Illinois 
      60612, USA. akanner@rush.edu
FAU - Barry, John J
AU  - Barry JJ
FAU - Gilliam, Frank
AU  - Gilliam F
FAU - Hermann, Bruce
AU  - Hermann B
FAU - Meador, Kimford J
AU  - Meador KJ
LA  - eng
GR  - K24 NS047551/NS/NINDS NIH HHS/United States
GR  - R01 NS040808/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
DEP - 20120503
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Anticonvulsants/*adverse effects
MH  - Anxiety Disorders/*chemically induced/diagnosis/*epidemiology
MH  - Depression/*chemically induced/diagnosis/*epidemiology
MH  - Epilepsy/drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Regression Analysis
EDAT- 2012/05/05 06:00
MHDA- 2012/08/10 06:00
CRDT- 2012/05/05 06:00
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - 10.1111/j.1528-1167.2012.03488.x [doi]
PST - ppublish
SO  - Epilepsia. 2012 Jun;53(6):1104-8. doi: 10.1111/j.1528-1167.2012.03488.x. Epub 
      2012 May 3.