PMID- 22554651
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20221207
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 12
IP  - 5
DP  - 2012 Jul
TI  - Genetic polymorphisms of CCL2, CCL5, CCR2 and CCR5 genes in Sahariya tribe of 
      North Central India: an association study with pulmonary tuberculosis.
PG  - 1120-7
LID - 10.1016/j.meegid.2012.03.018 [doi]
AB  - The association of genetic variants of chemokines, CCL2 [MCP-1 (monocyte 
      chemoattractant protein-1)], CCL5 [RANTES (regulated on activation, normal T-cell 
      expressed and secreted)] and their receptors CCR2 and CCR5, respectively, earlier 
      reported to be associated with susceptibility to pulmonary tuberculosis (PTB) in 
      certain ethnic populations, were explored in Sahariya tribe, a primitive tribe of 
      North Central India having a high prevalence of TB. We genotyped 215 cases and 
      215 controls of Sahariya tribe for polymorphisms in CCL2 (-2518A/G, -362G/C) by 
      PCR-RFLP method and in CCR2 (V64I), CCL5 (-403G/A, -28C/G) and CCR5 (-59029G/A) 
      by ARMS-PCR method. The frequencies of 'AA' genotype and 'A' allele of -403G/A 
      were found significantly higher in cases than in controls (OR, 2.616 [95%CI, 
      1.302-5.320] and OR, 1.348 [95%CI, 0.980-1.853], respectively). Conversely, the 
      frequencies of 'AA' genotype and 'A' allele of V64I were significantly (p=0.05 
      and 0.04, respectively) higher in controls than in cases. Also, the "AA" genotype 
      of V64I was found to provide significant (p=0.05) protection against high 
      bacillary load (3+). Likewise, the comparison of frequencies of different 
      combinations of these polymorphisms further strengthens the association of 
      -403G/A with susceptibility and V64I with resistance to TB in Sahariya tribe. 
      However, no significant association of other polymorphisms with either resistance 
      or susceptibility to TB was found. Thus, our findings support the association of 
      -403G/A and V64I polymorphisms with genetic susceptibility and resistance to TB, 
      respectively , alone or in combination with other polymorphisms in Sahariya 
      tribe.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Mishra, Gunja
AU  - Mishra G
AD  - Centre for Genomics, Molecular and Human Genetics, Jiwaji University, Gwalior 474 
      011, India.
FAU - Poojary, Satish S
AU  - Poojary SS
FAU - Raj, Prithvi
AU  - Raj P
FAU - Tiwari, Pramod Kumar
AU  - Tiwari PK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120328
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL5 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, CCR5)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/*genetics
MH  - Chemokine CCL5/*genetics
MH  - Chi-Square Distribution
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - India/epidemiology
MH  - Linkage Disequilibrium
MH  - Male
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, CCR2/*genetics
MH  - Receptors, CCR5/*genetics
MH  - Tuberculosis, Pulmonary/epidemiology/*genetics
MH  - White People/genetics
EDAT- 2012/05/05 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/05/05 06:00
PHST- 2011/12/13 00:00 [received]
PHST- 2012/03/14 00:00 [revised]
PHST- 2012/03/19 00:00 [accepted]
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - S1567-1348(12)00098-6 [pii]
AID - 10.1016/j.meegid.2012.03.018 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2012 Jul;12(5):1120-7. doi: 10.1016/j.meegid.2012.03.018. Epub 
      2012 Mar 28.