PMID- 22554780
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20220409
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 215
DP  - 2012 Jul 26
TI  - Differential effects of acute and regular physical exercise on cognition and 
      affect.
PG  - 59-68
LID - 10.1016/j.neuroscience.2012.04.056 [doi]
AB  - The effects of regular exercise versus a single bout of exercise on cognition, 
      anxiety, and mood were systematically examined in healthy, sedentary young adults 
      who were genotyped to determine brain-derived neurotrophic factor (BDNF) allelic 
      status (i.e., Val-Val or Val66Met polymorphism). Participants were evaluated on 
      novel object recognition (NOR) memory and a battery of mental health surveys 
      before and after engaging in either (a) a 4-week exercise program, with exercise 
      on the final test day, (b) a 4-week exercise program, without exercise on the 
      final test day, (c) a single bout of exercise on the final test day, or (d) 
      remaining sedentary between test days. Exercise enhanced object recognition 
      memory and produced a beneficial decrease in perceived stress, but only in 
      participants who exercised for 4 weeks including the final day of testing. In 
      contrast, a single bout of exercise did not affect recognition memory and 
      resulted in increased perceived stress levels. An additional novel finding was 
      that the improvements on the NOR task were observed exclusively in participants 
      who were homozygous for the BDNF Val allele, indicating that altered 
      activity-dependent release of BDNF in Met allele carriers may attenuate the 
      cognitive benefits of exercise. Importantly, exercise-induced changes in 
      cognition were not correlated with changes in mood/anxiety, suggesting that 
      separate neural systems mediate these effects. These data in humans mirror recent 
      data from our group in rodents. Taken together, these current findings provide 
      new insights into the behavioral and neural mechanisms that mediate the effects 
      of physical exercise on memory and mental health in humans.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Hopkins, M E
AU  - Hopkins ME
AD  - Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, 
      USA.
FAU - Davis, F C
AU  - Davis FC
FAU - Vantieghem, M R
AU  - Vantieghem MR
FAU - Whalen, P J
AU  - Whalen PJ
FAU - Bucci, D J
AU  - Bucci DJ
LA  - eng
GR  - R01 MH080716/MH/NIMH NIH HHS/United States
GR  - R01 MH082893/MH/NIMH NIH HHS/United States
GR  - R01MH082893/MH/NIMH NIH HHS/United States
GR  - R01MH080716/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120430
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Activities of Daily Living
MH  - Adolescent
MH  - Adult
MH  - Affect/*physiology
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Cognition/*physiology
MH  - Exercise/*physiology
MH  - Genetic Testing
MH  - Humans
MH  - Methionine/genetics
MH  - Mood Disorders/diagnosis/genetics
MH  - Neuropsychological Tests
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Psychiatric Status Rating Scales
MH  - Recognition, Psychology/physiology
MH  - Stress, Psychological/genetics/psychology
MH  - Valine/genetics
MH  - Young Adult
PMC - PMC3374855
MID - NIHMS373827
EDAT- 2012/05/05 06:00
MHDA- 2012/10/27 06:00
PMCR- 2013/07/26
CRDT- 2012/05/05 06:00
PHST- 2012/03/01 00:00 [received]
PHST- 2012/04/13 00:00 [revised]
PHST- 2012/04/20 00:00 [accepted]
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
PHST- 2013/07/26 00:00 [pmc-release]
AID - S0306-4522(12)00418-6 [pii]
AID - 10.1016/j.neuroscience.2012.04.056 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Jul 26;215:59-68. doi: 10.1016/j.neuroscience.2012.04.056. 
      Epub 2012 Apr 30.