PMID- 22555041
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20190608
IS  - 1677-6119 (Electronic)
IS  - 1677-5538 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Mar-Apr
TI  - Beneficial effect of ubiquinol, the reduced form of coenzyme Q10, on cyclosporine 
      nephrotoxicity.
PG  - 230-4; discussion 234
AB  - BACKGROUND: Cyclosporine (CyA) nephrotoxicity is partly due to some oxidative 
      stress. Ubiquinol, the reduced form of coenzyme Q10 (rCoQ10), has recently gained 
      attention for its anti-oxidative potential. The aim of this study is to evaluate 
      the effect of rCoQ10 on a CyA nephrotoxic rat model. MATERIALS AND METHODS: 
      Six-week-old male Wistar rats were divided into three groups (five animals each). 
      Group 1 received a medium only. Group 2 received 30 mg/kg/day of CyA only. Group 
      3 received both the same dose of CyA and 600 mg/kg/day of rCoQ10. CyA and rCoQ10 
      were both given orally for four weeks. Systolic blood pressure (BP), daily 
      urinary albumin secretion (u-Alb), serum creatinine (s-Cr) level, and super-oxide 
      anion (SO) level in the renal tissue were measured and compared among those three 
      groups. Immunohistochemistry using an antibody for the transforming growth 
      factor-beta (TGF-beta) was also examined. RESULTS: BPs, u-Albs, s-Crs, and SO 
      levels of groups 1, 2, and 3 were 114 +/- 3, 132 +/- 4, and 129 +/- 5 mmHg, 2.6 +/- 0.5, 
      42.1 +/- 7.2, and 22.8 +/- 3.4 micro-g/day, 1.1 +/- 0.2, 1.7 +/- 0.2, and 1.3 +/- 0.2 
      mg/dL, and 224 +/- 84, 1251 +/- 138, and 512 +/- 109 RLU/g kidney respectively. U-Albs, 
      s-Crs, and SO levels were signifi cantly ameliorated by rCoQ10. Micro-vacuolar 
      changes and TGF-beta positive deposits in the proximal renal tubular cells of CyA 
      group rats disappeared in those of CyA and rCoQ10 group rats. CONCLUSION: RCoQ10, 
      an antioxidants, may have potential for preventing CyA nephrotoxicity.
FAU - Ishikawa, Akira
AU  - Ishikawa A
AD  - Department of Urology, Graduate School of Medicine, the University of Tokyo, 
      Japan. ishikawaa-uro@h.u-tokyo.ac.jp
FAU - Homma, Yukio
AU  - Homma Y
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Int Braz J Urol
JT  - International braz j urol : official journal of the Brazilian Society of Urology
JID - 101158091
RN  - 0 (Antioxidants)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Micronutrients)
RN  - 0 (Transforming Growth Factor beta)
RN  - 1339-63-5 (Ubiquinone)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - AYI8EX34EU (Creatinine)
RN  - M9NL0C577Y (ubiquinol)
SB  - IM
MH  - Albuminuria/prevention & control
MH  - Animals
MH  - Antioxidants/administration & dosage
MH  - Creatinine/blood
MH  - Cyclosporine/*adverse effects
MH  - Dietary Supplements
MH  - Disease Models, Animal
MH  - Immunosuppressive Agents/*adverse effects
MH  - Kidney/drug effects/metabolism
MH  - Kidney Diseases/*chemically induced
MH  - Male
MH  - Micronutrients/*administration & dosage
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Transforming Growth Factor beta/metabolism
MH  - Ubiquinone/administration & dosage/*analogs & derivatives
EDAT- 2012/05/05 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/05/05 06:00
PHST- 2011/05/12 00:00 [accepted]
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - IBJUv38n2a10 [pii]
AID - 10.1590/s1677-55382012000200011 [doi]
PST - ppublish
SO  - Int Braz J Urol. 2012 Mar-Apr;38(2):230-4; discussion 234. doi: 
      10.1590/s1677-55382012000200011.