PMID- 22555265
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20211021
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 18
IP  - 5
DP  - 2012 May
TI  - IIIB or not IIIB: a previously unanswered question.
PG  - 367-72
LID - 10.1016/j.cardfail.2012.01.016 [doi]
AB  - The term New York Heart Association (NYHA) class IIIB has been used increasingly 
      in clinical medicine, including as an inclusion criteria for many clinical trials 
      assessing left ventricular assist devices (LVADs). Indeed, NYHA class IIIB is 
      incorporated in the Food and Drug Administration's approved indication for the 
      Heartmate II. However, on review of the medical literature, we found that there 
      is no consensus definition of NYHA class IIIB. Until the ambiguity is resolved, 
      we suggest that this designation not be used in clinical practice or by 
      investigators leading clinical trials assessing therapies which convey 
      substantial risk to patients and therefore require clarity in describing the 
      enrolled patient population. With ongoing improvements in LVADs, this therapy 
      will increasingly be considered in patients less sick than those who require 
      inotropic support, providing urgency to establish a consensus system of 
      classifying such patients who nevertheless fall within the spectrum of advanced 
      heart failure. Herein we propose a modification of the standard NYHA 
      classification system which can be used to fill this void.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Thibodeau, Jennifer T
AU  - Thibodeau JT
AD  - Division of Cardiology, Department of Internal Medicine, University of Texas 
      Southwestern Medical Center, Dallas, Texas 75390-9047, USA.
FAU - Mishkin, Joseph D
AU  - Mishkin JD
FAU - Patel, Parag C
AU  - Patel PC
FAU - Mammen, Pradeep P A
AU  - Mammen PP
FAU - Markham, David W
AU  - Markham DW
FAU - Drazner, Mark H
AU  - Drazner MH
LA  - eng
GR  - K08 HL076440/HL/NHLBI NIH HHS/United States
GR  - R01 HL102478/HL/NHLBI NIH HHS/United States
PT  - Editorial
DEP - 20120308
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - *American Heart Association
MH  - Heart Failure/*classification/physiopathology/therapy
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Treatment Outcome
MH  - United States
EDAT- 2012/05/05 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/05/05 06:00
PHST- 2011/09/08 00:00 [received]
PHST- 2012/01/13 00:00 [revised]
PHST- 2012/01/17 00:00 [accepted]
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S1071-9164(12)00039-5 [pii]
AID - 10.1016/j.cardfail.2012.01.016 [doi]
PST - ppublish
SO  - J Card Fail. 2012 May;18(5):367-72. doi: 10.1016/j.cardfail.2012.01.016. Epub 
      2012 Mar 8.