PMID- 22555266
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20220317
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 18
IP  - 5
DP  - 2012 May
TI  - Comparison of cardiac resynchronization therapy outcomes in patients with New 
      York Heart Association functional class I/II versus III/IV heart failure.
PG  - 373-8
LID - 10.1016/j.cardfail.2012.01.015 [doi]
AB  - BACKGROUND: Several randomized trials have shown that cardiac resynchronization 
      therapy (CRT) benefits New York Heart Association (NYHA) functional class I/II 
      heart failure (HF) patients, but it is unknown if similar outcomes occur in the 
      real-world. METHODS AND RESULTS: All patients receiving CRT between 2003 and 2008 
      with ejection fraction (EF) </=35% and QRS duration >/=120 ms were included. Outcomes 
      assessed were subjective clinical response, echocardiographic response, and 
      survival free of cardiovascular (CV) hospitalization. Baseline demographics in 
      functional class I/II (n = 155) and functional class III/IV (n = 512) were 
      similar, except for differences in age and several comorbidities. Clinical 
      response was similar in both groups. The functional class I/II group had a 
      greater decrease in left ventricular (LV) end-diastolic dimension (P = .031), and 
      trended toward greater improvements in LV end-systolic dimension (P = .056) and 
      EF (P = .059). The functional class I/II group had a better 5-year survival rate 
      (79 vs 54%; P < .0001) and survival free of CV hospitalization (45% vs 26%; P < 
      .0001). CONCLUSIONS: In this real-world clinical scenario, NYHA functional class 
      I/II CRT patients improved clinical status, and LV function and size as good as 
      or better than those in NYHA functional class III/IV patients. These observations 
      provide further support for the use of CRT in patients with mild symptoms of HF.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Bank, Alan J
AU  - Bank AJ
AD  - St Paul Heart Clinic and Allina Heart and Vascular Clinic, St Paul, Minnesota, 
      USA. alan.bank@allina.com
FAU - Rischall, Ariel
AU  - Rischall A
FAU - Gage, Ryan M
AU  - Gage RM
FAU - Burns, Kevin V
AU  - Burns KV
FAU - Kubo, Spencer H
AU  - Kubo SH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120302
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Aged
MH  - Cardiac Resynchronization Therapy/*methods
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/diagnostic imaging/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Ventricular Function, Left/*physiology
MH  - Ventricular Remodeling/*physiology
EDAT- 2012/05/05 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/05/05 06:00
PHST- 2011/10/11 00:00 [received]
PHST- 2011/12/21 00:00 [revised]
PHST- 2012/01/17 00:00 [accepted]
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S1071-9164(12)00038-3 [pii]
AID - 10.1016/j.cardfail.2012.01.015 [doi]
PST - ppublish
SO  - J Card Fail. 2012 May;18(5):373-8. doi: 10.1016/j.cardfail.2012.01.015. Epub 2012 
      Mar 2.