PMID- 22555267
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20181201
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 18
IP  - 5
DP  - 2012 May
TI  - Long-term effect of bosentan therapy on cardiac function and symptomatic benefits 
      in adult patients with Eisenmenger syndrome.
PG  - 379-84
LID - 10.1016/j.cardfail.2012.02.004 [doi]
AB  - BACKGROUND: Bosentan improves symptoms in patients with Eisenmenger syndrome 
      (ES). This study evaluated the effect of long-term bosentan therapy on cardiac 
      function and its relation to symptomatic benefits in ES patients. METHODS AND 
      RESULTS: Twenty-three consecutive adult ES patients (15 with ventricular septal 
      defect, 6 with atrial septal defect, and 2 with patent ductus arteriosus) 
      underwent standard and tissue Doppler echocardiography before and 24 +/- 9 months 
      after bosentan therapy. Echocardiographic measurements included pulmonary 
      arterial systolic pressure (PASP), myocardial performance index (MPI), tricuspid 
      and lateral mitral annular pulsed-wave tissue Doppler systolic (Sa) and early 
      diastolic (Ea) long-axis motions. Patients' World Health Organization (WHO) 
      functional class, 6-minute walk distance (6MWD), and systemic arterial oxygen 
      saturations (SaO(2)) were also recorded. The PASP, WHO functional class, 6MWD, 
      and SaO(2) all improved (118 +/- 22 to 111 +/- 19 mm Hg, 3.2 +/- 0.4 to 2.4 +/- 0.5, 286 
      +/- 129 m to 395 +/- 120 m, and 84.6 +/- 6.5% to 88.8 +/- 3.9%, respectively; all P < 
      .01) after therapy. There was also significant improvement in right ventricular 
      (RV) MPI (by 23.9%: 0.46 +/- 0.15 to 0.35 +/- 0.09) and biventricular long-axis 
      function (tricuspid Sa and Ea: 6.7 +/- 1.5 to 8.8 +/- 1.7 cm/s and 5.7 +/- 1.3 to 7.0 +/- 
      1.2 cm/s, respectively; lateral Sa and Ea: 6.8 +/- 1.3 to 8.4 +/- 1.5 cm/s and 7.6 +/- 
      2.0 to 8.5 +/- 2.1 cm/s, respectively; all P < .05). Posttherapy RV MPI was 
      moderately correlated with PASP and 6MWD. CONCLUSIONS: Sustained improvement of 
      pulmonary arterial hypertension and RV function in ES patients was evident 2 
      years after bosentan therapy, and this may provide insights on the symptomatic 
      benefits gained in these patients.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kaya, Mehmet G
AU  - Kaya MG
AD  - Department of Cardiology, Erciyes University Medicine School, Kayseri, Turkey.
FAU - Lam, Yat-Yin
AU  - Lam YY
FAU - Erer, Betul
AU  - Erer B
FAU - Ayhan, Selim
AU  - Ayhan S
FAU - Vatankulu, Mehmet A
AU  - Vatankulu MA
FAU - Nurkalem, Zekeriya
AU  - Nurkalem Z
FAU - Meric, Murat
AU  - Meric M
FAU - Eren, Mehmet
AU  - Eren M
FAU - Eryol, Namik K
AU  - Eryol NK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120310
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Sulfonamides)
RN  - Q326023R30 (Bosentan)
SB  - IM
CIN - J Card Fail. 2012 May;18(5):385-6. PMID: 22555268
MH  - Adult
MH  - Antihypertensive Agents/administration & dosage/therapeutic use
MH  - Bosentan
MH  - Diastole
MH  - Dose-Response Relationship, Drug
MH  - Echocardiography, Doppler
MH  - Eisenmenger Complex/diagnosis/*drug therapy/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles/drug effects/physiopathology
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Pulmonary Wedge Pressure/drug effects
MH  - Sulfonamides/administration & dosage/*therapeutic use
MH  - Systole
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Right/*drug effects
EDAT- 2012/05/05 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/05/05 06:00
PHST- 2011/09/15 00:00 [received]
PHST- 2012/01/10 00:00 [revised]
PHST- 2012/02/06 00:00 [accepted]
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S1071-9164(12)00075-9 [pii]
AID - 10.1016/j.cardfail.2012.02.004 [doi]
PST - ppublish
SO  - J Card Fail. 2012 May;18(5):379-84. doi: 10.1016/j.cardfail.2012.02.004. Epub 
      2012 Mar 10.