PMID- 22555311
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20211021
IS  - 1364-548X (Electronic)
IS  - 1359-7345 (Print)
IS  - 1359-7345 (Linking)
VI  - 48
IP  - 47
DP  - 2012 Jun 14
TI  - Engineering of lipid-coated PLGA nanoparticles with a tunable payload of 
      diagnostically active nanocrystals for medical imaging.
PG  - 5835-7
LID - 10.1039/c2cc32149a [doi]
AB  - Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and 
      biodegradable and therefore have been extensively investigated as therapeutic 
      carriers. Here, we engineered diagnostically active PLGA nanoparticles that 
      incorporate high payloads of nanocrystals into their core for tunable bioimaging 
      features. We accomplished this through esterification reactions of PLGA to 
      generate polymers modified with nanocrystals. The PLGA nanoparticles formed from 
      modified PLGA polymers that were functionalized with either gold nanocrystals or 
      quantum dots exhibited favorable features for computed tomography and optical 
      imaging, respectively.
FAU - Mieszawska, Aneta J
AU  - Mieszawska AJ
AD  - Translational and Molecular Imaging Institute and Imaging Science Laboratories, 
      Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 
      10029, USA.
FAU - Gianella, Anita
AU  - Gianella A
FAU - Cormode, David P
AU  - Cormode DP
FAU - Zhao, Yiming
AU  - Zhao Y
FAU - Meijerink, Andries
AU  - Meijerink A
FAU - Langer, Robert
AU  - Langer R
FAU - Farokhzad, Omid C
AU  - Farokhzad OC
FAU - Fayad, Zahi A
AU  - Fayad ZA
FAU - Mulder, Willem J M
AU  - Mulder WJ
LA  - eng
GR  - HHSN268201000045C/HL/NHLBI NIH HHS/United States
GR  - K99 EB012165/EB/NIBIB NIH HHS/United States
GR  - R00 EB012165/EB/NIBIB NIH HHS/United States
GR  - R01 CA155432/CA/NCI NIH HHS/United States
GR  - R01 EB009638/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120503
PL  - England
TA  - Chem Commun (Camb)
JT  - Chemical communications (Cambridge, England)
JID - 9610838
RN  - 0 (11-mercaptoundecanoic acid)
RN  - 0 (11-mercaptoundecanol)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Alcohols)
RN  - 0 (Sulfhydryl Compounds)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Diagnostic Imaging
MH  - Fatty Acids/*chemistry
MH  - Fatty Alcohols/*chemistry
MH  - Gold/*chemistry
MH  - Metal Nanoparticles/*chemistry/ultrastructure
MH  - Microscopy, Electron, Transmission
MH  - Polyglycolic Acid/*chemistry
MH  - *Quantum Dots
MH  - Sulfhydryl Compounds/*chemistry
PMC - PMC3593599
MID - NIHMS443762
EDAT- 2012/05/05 06:00
MHDA- 2012/09/19 06:00
PMCR- 2013/03/11
CRDT- 2012/05/05 06:00
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
PHST- 2013/03/11 00:00 [pmc-release]
AID - 10.1039/c2cc32149a [doi]
PST - ppublish
SO  - Chem Commun (Camb). 2012 Jun 14;48(47):5835-7. doi: 10.1039/c2cc32149a. Epub 2012 
      May 3.