PMID- 22557799
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1998-3913 (Electronic)
IS  - 0971-6203 (Print)
IS  - 0971-6203 (Linking)
VI  - 37
IP  - 2
DP  - 2012 Apr
TI  - A case study for online plan adaptation using helical tomotherapy.
PG  - 97-101
LID - 10.4103/0971-6203.94744 [doi]
AB  - Helical tomotherapy's ability to provide daily megavoltage (MV) computed 
      tomography (CT) images for patient set-up verification allows for the creation of 
      adapted plans. As plans become more complex by introducing sharper dose gradients 
      in an effort to spare healthy tissue, inter-fraction changes of organ position 
      with respect to plan become a limiting factor in the correct dose delivery to the 
      target. Tomotherapy's planned adaptive option provides the possibility to 
      evaluate the dose distribution for each fraction and subsequently adapt the 
      original plan to the current anatomy. In this study, 30 adapted plans were 
      created using new contours based on the daily MVCT studies of a bladder cancer 
      patient with considerable anatomical variations. Dose to the rectum and two 
      planning target volumes (PTVs) were compared between the original plan, the dose 
      that was actually delivered to the patient, and the theoretical dose from the 30 
      adapted plans. The adaptation simulation displayed a lower dose to 35% and 50% of 
      the rectum compared to no adaptation at all, while maintaining an equivalent dose 
      to the PTVs. Although online adaptation is currently too time-consuming, it has 
      the potential to improve the effectiveness of radiotherapy.
FAU - Neilson, Christopher E
AU  - Neilson CE
AD  - London Regional Cancer Program, London Health Sciences Centre, London, Ontario, 
      Canada.
FAU - Yartsev, Slav
AU  - Yartsev S
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Med Phys
JT  - Journal of medical physics
JID - 9441104
PMC - PMC3339149
OTO - NOTNLM
OT  - Adaptive radiation therapy
OT  - bladder cancer
OT  - replanning
COIS- Conflict of Interest: None declared.
EDAT- 2012/05/05 06:00
MHDA- 2012/05/05 06:01
PMCR- 2012/04/01
CRDT- 2012/05/05 06:00
PHST- 2011/08/23 00:00 [received]
PHST- 2011/10/15 00:00 [revised]
PHST- 2011/12/23 00:00 [accepted]
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/05/05 06:01 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - JMP-37-97 [pii]
AID - 10.4103/0971-6203.94744 [doi]
PST - ppublish
SO  - J Med Phys. 2012 Apr;37(2):97-101. doi: 10.4103/0971-6203.94744.