PMID- 22558518
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2045-8940 (Electronic)
IS  - 2045-8932 (Print)
IS  - 2045-8932 (Linking)
VI  - 2
IP  - 1
DP  - 2012 Jan-Mar
TI  - Three-dimensional analysis of right ventricular shape and function in pulmonary 
      hypertension.
PG  - 34-40
LID - 10.4103/2045-8932.94828 [doi]
AB  - Right ventricular (RV) failure is a key determinant of morbidity and mortality in 
      pulmonary hypertension (PH). The present study aims to add to existing 
      descriptions of RV structural and functional changes in PH through a 
      comprehensive three-dimensional (3D) shape analysis. We performed 3D 
      echocardiography on 53 subjects with PH and 19 normal subjects. Twenty short-axis 
      slices from apex to tricuspid centroid were measured to characterize regional 
      shape: apical angle, basal bulge, eccentricity, and area. Transverse shortening 
      was assessed by fractional area change (FAC) in each short-axis slice, 
      longitudinal contraction was assessed by tricuspid annular plane systolic 
      excursion (TAPSE) and global function by RV ejection fraction. Multivariate 
      logistic analysis was used to compare the association of RV parameters with New 
      York Heart Association (NYHA) class. Compared to normal, RV function in PH is 
      characterized by decreased stroke volume index (SVi), fractional area change and 
      ejection fraction. Increased eccentricity, apical rounding and bulging at the 
      base characterize the shape of the RV in PH. Increased SVi, ejection fraction and 
      mid-ventricular FAC were associated with less severe NYHA class in adjusted 
      analyses. The RV in idiopathic PH (iPAH) was observed to have a larger 
      end-diastolic volume and decreased function compared with connective tissue 
      disease associated PH (ctd-PH). This work describes increased eccentricity and 
      decreased systolic function in subjects with PH. Functional parameters were 
      associated with NYHA class and heterogeneity in the phenotype was noted between 
      subjects with iPAH and ctd-PH.
FAU - Leary, Peter J
AU  - Leary PJ
AD  - University of Washington, Division of Pulmonary and Critical Care, Seattle, 
      Washington, USA.
FAU - Kurtz, Christopher E
AU  - Kurtz CE
FAU - Hough, Catherine L
AU  - Hough CL
FAU - Waiss, Mary-Pierre
AU  - Waiss MP
FAU - Ralph, David D
AU  - Ralph DD
FAU - Sheehan, Florence H
AU  - Sheehan FH
LA  - eng
GR  - T32 HL007287/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Pulm Circ
JT  - Pulmonary circulation
JID - 101557243
PMC - PMC3342747
OTO - NOTNLM
OT  - 3D echocardiography
OT  - pulmonary hypertension
OT  - right ventricle
COIS- Conflict of Interest: PJL, CEK, CLH and DDR report no conflicts of interest. FHS 
      is a scientific and technical consultant for Ventripoint, Inc. (markets an 
      alternative method of 3D echocardiographic reconstruction). MPW is an employee of 
      Ventripoint, Inc.
EDAT- 2012/05/05 06:00
MHDA- 2012/05/05 06:01
PMCR- 2012/01/01
CRDT- 2012/05/05 06:00
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/05/05 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - PC-2-34 [pii]
AID - 10.4103/2045-8932.94828 [doi]
PST - ppublish
SO  - Pulm Circ. 2012 Jan-Mar;2(1):34-40. doi: 10.4103/2045-8932.94828.