PMID- 22558610
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20191210
IS  - 1064-6655 (Print)
IS  - 1064-6655 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Spring
TI  - Conditioned pain modulation evoked by a mechanical craniofacial stimulus is not 
      influenced by noxious stimulation of the temporomandibular joint.
PG  - 105-16
AB  - AIMS: To investigate the influence of noxious stimulation of the 
      temporomandibular joint (TMJ) on conditioned pain modulation (CPM) and the 
      possible influence of gender on such CPM effects in the craniofacial region of 
      humans. METHODS: Twenty healthy men and 20 healthy women participated in two 
      sessions. Conditioning stimulation (CS) was standardized mechanical stimulation 
      of pericranial muscles at a pain level of 5 on a 0 to 10 visual analog scale 
      (VAS). Intra-articular electrical stimuli were applied to the left TMJ with an 
      intensity around VAS = 5 (painful session). No electrical stimulation was applied 
      in the control session. Pressure pain threshold (PPT) and pressure pain tolerance 
      threshold (PPTol) were used as responses to pressure (test) stimuli and were 
      assessed in the right masseter muscle and left forearm before and during TMJ 
      stimulation in addition to the CS (during, immediately after, and 10 minutes 
      after CS). PPT and PPTol were analyzed by multilevel analysis of variance. 
      RESULTS: The parameters were not dependent on gender, assessment site, or 
      session, but were dependent on time (PPT, PPTol: P < .001) with session-time 
      interactions (PPT: P < .001, PPTol: P = .002). CS triggered increases in PPT and 
      PPTol (hypoalgesia) in both sessions and without significant differences between 
      sessions or assessment sites during CS (painful session: 49.2 +/- 3.7%, control 
      session: 46.0 +/- 3.4% for PPT and painful session: 17.7 +/- 3.2%, control session: 
      21.4 +/- 3.5% for PPTol). CONCLUSION: Acute noxious stimulation of the TMJ does not 
      alter the magnitude of CPM effects on masseter muscle pain in either gender. It 
      is suggested that deficiencies in CPM in persistent pain conditions are most 
      likely more related to the duration of clinical pain than the pain per se.
FAU - Oono, Yuka
AU  - Oono Y
AD  - Center for Sensory-Motor Interaction, Department of Health Science and 
      Technology, Falculty of Medicine, Aalborg University, Aalborg, Denmark.
FAU - Wang, Kelun
AU  - Wang K
FAU - Svensson, Peter
AU  - Svensson P
FAU - Arendt-Nielsen, Lars
AU  - Arendt-Nielsen L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Orofac Pain
JT  - Journal of orofacial pain
JID - 9418507
MH  - Adult
MH  - Analysis of Variance
MH  - Conditioning, Psychological/*physiology
MH  - Diffuse Noxious Inhibitory Control/*physiology
MH  - Electric Stimulation
MH  - Facial Pain/*physiopathology
MH  - Female
MH  - Forearm/physiopathology
MH  - Humans
MH  - Male
MH  - Masseter Muscle/physiopathology
MH  - Pain Measurement
MH  - Pain Threshold/physiology
MH  - Physical Stimulation
MH  - Pressure
MH  - Sex Factors
MH  - Temporomandibular Joint/*physiopathology
MH  - Young Adult
EDAT- 2012/05/05 06:00
MHDA- 2012/06/27 06:00
CRDT- 2012/05/05 06:00
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
PST - ppublish
SO  - J Orofac Pain. 2012 Spring;26(2):105-16.