PMID- 22559213
OWN - NLM
STAT- MEDLINE
DCOM- 20130625
LR  - 20191210
IS  - 1366-5928 (Electronic)
IS  - 0049-8254 (Linking)
VI  - 42
IP  - 10
DP  - 2012 Oct
TI  - Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and 
      intestinal glucuronidation of phytochemical carvacrol.
PG  - 1009-16
LID - 10.3109/00498254.2012.682614 [doi]
AB  - 1. Carvacrol (2-methyl-5-(1-methylethyl)-phenol), one of the main components 
      occurring in many essential oils of the family Labiatae, has been widely used in 
      food, spice and pharmaceutical industries. 2. The carvacrol glucuronidation was 
      characterized by human liver microsomes (HLMs), human intestinal microsomes 
      (HIMs) and 12 recombinant UGT (rUGT) isoforms. 3. One metabolite was identified 
      as a mono-glucuronide by liquid chromatography/mass spectrometry with HLMs, HIMs, 
      rUGT1A3, rUGT1A6, rUGT1A7, rUGT1A9 and rUGT2B7. 4. The study with a chemical 
      inhibition, rUGT, and kinetics study demonstrated that rUGT1A9 was the major 
      isozyme responsible for glucuronidation in HLMs, and rUGT1A7 played a major role 
      for glucuronidation in HIMs.
FAU - Dong, Rui-Hua
AU  - Dong RH
AD  - Department of Clinical Pharmacology, Affiliated Hospital, Academy of Military 
      Medical Sciences, Beijing, China.
FAU - Fang, Zhong-Ze
AU  - Fang ZZ
FAU - Zhu, Liang-Liang
AU  - Zhu LL
FAU - Ge, Guang-Bo
AU  - Ge GB
FAU - Yang, Ling
AU  - Yang L
FAU - Liu, Ze-Yuan
AU  - Liu ZY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120504
PL  - England
TA  - Xenobiotica
JT  - Xenobiotica; the fate of foreign compounds in biological systems
JID - 1306665
RN  - 0 (Cymenes)
RN  - 0 (Glucuronides)
RN  - 0 (Isoenzymes)
RN  - 0 (Monoterpenes)
RN  - 0 (Recombinant Proteins)
RN  - 9B1J4V995Q (carvacrol)
RN  - EC 2.4.1.17 (Glucuronosyltransferase)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Chromatography, High Pressure Liquid
MH  - Cymenes
MH  - Enzyme Assays
MH  - Female
MH  - Glucuronides/*metabolism
MH  - Glucuronosyltransferase/*metabolism
MH  - Humans
MH  - Intestines/drug effects/*enzymology
MH  - Isoenzymes/metabolism
MH  - Kinetics
MH  - Liver/drug effects/*enzymology
MH  - Male
MH  - Microsomes, Liver/drug effects/enzymology
MH  - Middle Aged
MH  - Monoterpenes/chemistry
MH  - Propofol/pharmacology
MH  - Recombinant Proteins/metabolism
MH  - Young Adult
EDAT- 2012/05/09 06:00
MHDA- 2013/06/26 06:00
CRDT- 2012/05/08 06:00
PHST- 2012/05/08 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - 10.3109/00498254.2012.682614 [doi]
PST - ppublish
SO  - Xenobiotica. 2012 Oct;42(10):1009-16. doi: 10.3109/00498254.2012.682614. Epub 
      2012 May 4.