PMID- 22559939
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20161125
IS  - 1937-6448 (Print)
IS  - 1937-6448 (Linking)
VI  - 296
DP  - 2012
TI  - Hypoxia and hypoxia signaling in tissue repair and fibrosis.
PG  - 139-85
LID - 10.1016/B978-0-12-394307-1.00003-5 [doi]
AB  - Following injury, vascular damage results in the loss of perfusion and consequent 
      low oxygen tension (hypoxia) which may be exacerbated by a rapid influx of 
      inflammatory and mesenchymal cells with high metabolic demands for oxygen. 
      Changes in systemic and cellular oxygen concentrations induce tightly regulated 
      response pathways that attempt to restore oxygen supply to cells and modulate 
      cell function in hypoxic conditions. Most of these responses occur through the 
      induction of the transcription factor hypoxia-inducible factor-1 (HIF-1) which 
      regulates many processes needed for tissue repair during ischemia in the damaged 
      tissue. HIF-1 transcriptionally upregulates expression of metabolic proteins 
      (GLUT-1), adhesion proteins (integrins), soluble growth factors (TGF-beta and VEGF), 
      and extracellular matrix components (type I collagen and fibronectin), which 
      enhance the repair process. For these reasons, HIF-1 is viewed as a positive 
      regulator of wound healing and a potential regulator of organ repair and tissue 
      fibrosis. Understanding the complex role of hypoxia in the loss of function in 
      scarring tissues and biology of chronic wound, and organ repair will aid in the 
      development of pharmaceutical agents that can redress the detrimental outcomes 
      often seen in repair and scarring.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Lokmic, Zerina
AU  - Lokmic Z
AD  - Department of Surgery, St. Vincent's Hospital, University of Melbourne, Fitzroy, 
      Victoria, Australia.
FAU - Musyoka, James
AU  - Musyoka J
FAU - Hewitson, Timothy D
AU  - Hewitson TD
FAU - Darby, Ian A
AU  - Darby IA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Int Rev Cell Mol Biol
JT  - International review of cell and molecular biology
JID - 101475846
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Fibrosis/*metabolism
MH  - Humans
MH  - Hypoxia/*metabolism
MH  - Hypoxia-Inducible Factor 1/metabolism
MH  - Oxygen/metabolism
MH  - *Signal Transduction
MH  - *Wound Healing
EDAT- 2012/05/09 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/05/08 06:00
PHST- 2012/05/08 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - B978-0-12-394307-1.00003-5 [pii]
AID - 10.1016/B978-0-12-394307-1.00003-5 [doi]
PST - ppublish
SO  - Int Rev Cell Mol Biol. 2012;296:139-85. doi: 10.1016/B978-0-12-394307-1.00003-5.