PMID- 22561999
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20120507
IS  - 1473-6527 (Electronic)
IS  - 0951-7375 (Linking)
VI  - 25
IP  - 3
DP  - 2012 Jun
TI  - The burden of nonencapsulated Haemophilus influenzae in children and potential 
      for prevention.
PG  - 266-72
LID - 10.1097/QCO.0b013e32835310a4 [doi]
AB  - PURPOSE OF REVIEW: In countries with established Haemophilus influenzae serotype 
      b (Hib) immunization programmes, nonencapsulated H. influenzae (ncHi) is 
      responsible for most invasive H. influenzae infections across all age groups and 
      is associated with higher case fatality. A pneumococcal conjugate vaccine has 
      recently been licensed, which may potentially also protect against invasive H. 
      influenzae infections. RECENT FINDINGS: Invasive ncHi disease is uncommon in 
      childhood but has a much higher incidence in the first month of life. Most 
      neonates with invasive ncHi infections are born prematurely and develop 
      septicaemia in the first 48 h of life which can be fatal. After this period, 
      invasive ncHi incidence falls rapidly and remains low throughout childhood. Most 
      infants and children who develop invasive ncHi disease have significant 
      underlying comorbidities, particularly neurological disease, malignancy and other 
      conditions requiring immunosuppressive therapy. Although characteristically 
      associated with respiratory tract infections, at least a quarter of invasive ncHi 
      infections present with meningitis. SUMMARY: A vaccine against ncHi could have an 
      important preventive role in children with comorbidities. Future studies should 
      focus on assessing specific risk factors for neonatal and childhood ncHi disease 
      and long-term outcomes of children with invasive ncHi meningitis.
FAU - Gkentzi, Despoina
AU  - Gkentzi D
AD  - St. George's University of London, Cranmer Terrace, London, UK.
FAU - Slack, Mary P E
AU  - Slack MP
FAU - Ladhani, Shamez N
AU  - Ladhani SN
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Infect Dis
JT  - Current opinion in infectious diseases
JID - 8809878
RN  - 0 (Haemophilus Vaccines)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Haemophilus Infections/epidemiology/*microbiology/*prevention & control
MH  - Haemophilus Vaccines/*administration & dosage
MH  - *Haemophilus influenzae/immunology/pathogenicity
MH  - Haemophilus influenzae type b/immunology/pathogenicity
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Influenza, Human/*microbiology/*prevention & control
MH  - Risk Factors
EDAT- 2012/05/09 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/05/08 06:00
PHST- 2012/05/08 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 00001432-201206000-00006 [pii]
AID - 10.1097/QCO.0b013e32835310a4 [doi]
PST - ppublish
SO  - Curr Opin Infect Dis. 2012 Jun;25(3):266-72. doi: 10.1097/QCO.0b013e32835310a4.