PMID- 22563222
OWN - NLM
STAT- MEDLINE
DCOM- 20120831
LR  - 20211021
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 27
IP  - 5
DP  - 2012 May
TI  - Hepatic ischemic preconditioning provides protection against distant renal 
      ischemia and reperfusion injury in mice.
PG  - 547-52
LID - 10.3346/jkms.2012.27.5.547 [doi]
AB  - We previously demonstrated that there are acute and delayed phases of renal 
      protection against renal ischemia and reperfusion (IR) injury with renal ischemic 
      preconditioning (IPC). This study assessed whether hepatic IPC could also reduce 
      distant renal IR injury through the blood stream-mediated supply of reactive 
      oxygen species (ROS). Male C57BL/6 mice were randomly divided into four groups: 
      group I, sham operated including right nephrectomy; group II (IR), left renal 
      ischemia for 30 min and reperfusion injury; group III (IPC-IR), hepatic ischemia 
      for 10 min followed by 10 min of reperfusion before left renal IR injury; group 
      IV (MPG - IPC + IR), pretreated with 100 mg/kg N-(2-mercaptopropionyl)-glycine 
      (MPG) 15 min before hepatic IPC and left renal IR injury. Renal function, 
      histopathologic findings, proinflammatory cytokines, and cytoprotective proteins 
      were evaluated 15 min or 24 hr after reperfusion. Hepatic IPC attenuated the 
      expression of proinflammatory cytokines, tumor necrosis factor alpha, intercellular 
      adhesion molecule 1, and induced inducible nitric-oxide synthase, and the 
      phosphorylation of Akt in the murine kidney. Renal function was better preserved 
      in mice with hepatic IPC (group III) than groups II or IV. Hepatic IPC protects 
      against distant renal IR injury through the blood stream-delivery of hepatic 
      IPC-induced ROS, by inducing cytoprotective proteins, and by inhibiting 
      inflammatory reactions.
FAU - Lee, Jung Ah
AU  - Lee JA
AD  - Department of Anesthesiology and Pain Medicine, Saint Vincent Hospital, The 
      Catholic University of Korea College of Medicine, Suwon, Korea.
FAU - Choi, Jin Woo
AU  - Choi JW
FAU - In, Jang Hyeok
AU  - In JH
FAU - Jung, Hong Soo
AU  - Jung HS
FAU - Kim, Yong Shin
AU  - Kim YS
FAU - Jeon, Yeon Soo
AU  - Jeon YS
FAU - Kang, Yoo Jin
AU  - Kang YJ
FAU - Kim, Dae Woo
AU  - Kim DW
FAU - Lim, Yong Gul
AU  - Lim YG
FAU - Park, Jae Hee
AU  - Park JH
FAU - Joo, Jin Deok
AU  - Joo JD
LA  - eng
PT  - Journal Article
DEP - 20120425
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - C5W04GO61S (Tiopronin)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Intercellular Adhesion Molecule-1/genetics/metabolism
MH  - *Ischemic Preconditioning
MH  - Kidney/drug effects/metabolism/pathology/physiopathology
MH  - Liver/blood supply/drug effects/physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Reperfusion Injury/*metabolism/pathology/prevention & control
MH  - Tiopronin/pharmacology
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
PMC - PMC3342548
OTO - NOTNLM
OT  - Cytoprotective Proteins
OT  - Ischemia and Reperfusion (IR) Injury
OT  - Ischemic Preconditioning (IPC)
OT  - Proinflammatory Cytokines
EDAT- 2012/05/09 06:00
MHDA- 2012/09/01 06:00
PMCR- 2012/05/01
CRDT- 2012/05/08 06:00
PHST- 2011/05/06 00:00 [received]
PHST- 2011/10/17 00:00 [accepted]
PHST- 2012/05/08 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/09/01 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - 10.3346/jkms.2012.27.5.547 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2012 May;27(5):547-52. doi: 10.3346/jkms.2012.27.5.547. Epub 
      2012 Apr 25.