PMID- 22563225
OWN - NLM
STAT- MEDLINE
DCOM- 20120831
LR  - 20211021
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 27
IP  - 5
DP  - 2012 May
TI  - A rare case of primary hyperparathyroidism associated with primary aldosteronism, 
      Hurthle cell thyroid cancer and meningioma.
PG  - 560-4
LID - 10.3346/jkms.2012.27.5.560 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) syndrome includes varying combinations 
      of endocrine and non-endocrine tumors. There are also a considerable number of 
      atypical MEN1 syndrome. In this case, a 68-yr-old woman was referred to the 
      Department of Endocrinology for hypercalcemia. Five years ago, she had diagnosed 
      as primary hyperaldosteronism and now newly diagnosed as parathyroid hyperplasia 
      with laboratory and pathologic findings. Hurthle-cell thyroid cancer was also 
      resected during the parathyroid exploration and small meningioma was found on 
      brain MRI. Her general condition has markedly improved and her adrenal mass and 
      meningioma are being closely observed now. We could find the loss of 
      heterozygosity of the MEN1 locus in parathyroid glands, suggesting a MEN1-related 
      tumor, but not a germline mutation. Considering a variety of phenotypic 
      expression and a limitation of current molecular analysis, periodic follow up 
      will be needed in patients with a MEN1-like phenotype.
FAU - Kim, You Lim
AU  - Kim YL
AD  - Department of Internal Medicine, Eulji University School of Medicine, Seoul, 
      Korea.
FAU - Jang, Young Woo
AU  - Jang YW
FAU - Kim, Jin Taek
AU  - Kim JT
FAU - Sung, Su Ah
AU  - Sung SA
FAU - Lee, Tae Seok
AU  - Lee TS
FAU - Lee, Won Mi
AU  - Lee WM
FAU - Kim, Hyo Jeong
AU  - Kim HJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120425
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - Thyroid cancer, Hurthle cell
SB  - IM
MH  - Adenoma, Oxyphilic
MH  - Aged
MH  - Base Sequence
MH  - Brain/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Hyperaldosteronism/complications/*diagnosis
MH  - Hyperparathyroidism, Primary/*diagnosis/etiology/pathology
MH  - Loss of Heterozygosity
MH  - Magnetic Resonance Imaging
MH  - Meningeal Neoplasms/complications/*diagnosis/diagnostic imaging
MH  - Meningioma/complications/*diagnosis/diagnostic imaging
MH  - Mutation
MH  - Parathyroid Glands/pathology
MH  - Proto-Oncogene Proteins/genetics/metabolism
MH  - Radionuclide Imaging
MH  - Sequence Analysis, DNA
MH  - Thyroid Neoplasms/complications/*diagnosis/pathology
MH  - Tomography, X-Ray Computed
PMC - PMC3342551
OTO - NOTNLM
OT  - Hyperparathyroidism
OT  - Meningioma
OT  - Primary Hyperaldosteronism
OT  - Thyroid Cancer, Hurthle-cell
EDAT- 2012/05/09 06:00
MHDA- 2012/09/01 06:00
PMCR- 2012/05/01
CRDT- 2012/05/08 06:00
PHST- 2011/10/30 00:00 [received]
PHST- 2012/01/26 00:00 [accepted]
PHST- 2012/05/08 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/09/01 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - 10.3346/jkms.2012.27.5.560 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2012 May;27(5):560-4. doi: 10.3346/jkms.2012.27.5.560. Epub 
      2012 Apr 25.